YRC Public Data Repository - Protein Structure Prediction

Protein:	sec1
Organism:	Schizosaccharomyces pombe
Length:	693 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sec1.

Description	E-value	Query Range	Subject Range
gi\|13097489 - gi\|13097489\|gb\|AAH03477.1\| Stxbp2 protein [Mus musculus]	611.0	[0..1]	[601..3]
gi\|7321218, gi\|1... - gi\|7321218\|emb\|CAA73264.2\| sec1-like protein [Loligo pealei], gi\|13096246\|pdb\|1FVH\|A Chain A, Crysta...	610.0	[0..1]	[594..1]
STXBP2 - syntaxin binding protein 2 gi\|208967548 - gi\|208967548\|dbj\|BAG73788.1\| syntaxin binding protein 2 [synthetic construct]	609.0	[0..3]	[601..6]
gi\|197102274 - gi\|197102274\|ref\|NP_001124900.1\| syntaxin binding protein 2 [Pongo abelii] gi\|55726287 - gi\|55726287\|emb\|CAH89915.1\| hypothetical protein [Pongo abelii]	607.0	[0..3]	[601..6]
STXB2_CANLF - Syntaxin-binding protein 2 OS=Canis lupus familiaris GN=STXBP2 PE=2 SV=1	607.0	[0..3]	[601..6]
gi\|114051133, gi... - gi\|84708888\|gb\|AAI11246.1\| Syntaxin binding protein 2 [Bos taurus], gi\|114051133\|ref\|NP_001039673.1\|...	604.0	[0..3]	[601..6]
gi\|114674991 - gi\|114674991\|ref\|XP_001153467.1\| PREDICTED: syntaxin binding protein 2 isoform 2 [Pan troglodytes]	602.0	[0..3]	[601..6]

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Predicted Domain #1

Region A:
Residues: [1-599]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLELQKEL FLSKINSVEC ATKWKVLIVD TKTADIINHF ITIHSLLEEK IAAVEILENP  60
   61 RTPNSSFEAL YILHSEEKLV DCILKDEEYD KRYPGIHIVF LDMVKEPLIN KLRTSRIASK 120
  121 IRTVQVAYLD FTSLESRYFQ VHDSFSGLRL YHPSNAAIIR QELSKVAHGI FSVCVSLGIS 180
  181 PNIRCYYPKN APHASKTMSF ILANQLSEIV EEYCSKHPGY HEAASKSTCL IVDRSLDTAA 240
  241 PFLHEFTYQA MIHDLLPIKN EQYPYEILGP QGTEKRTGKL DDDDLVYTTI RHMHMRDAIE 300
  301 KLMKDFNQFC IDNTLFLDKE RATSLNDMRS MLAGLSDFQE LRDQYSLHLT MAQECMNIFE 360
  361 KQQLNLIGAI EQDLSTGSNV EGKVPRSVLS ELLPLLDEGN AEESTKIRLL LLYIIYRDGI 420
  421 ILQDLFRLFR HSNLSTSREQ IFQNLEQLGT RVIKNLTDQS SKRKEVANSL PAGEDVYELS 480
  481 RYVPTLKVVL ENLIQDKLDP ELFPYVRNTT PQTEVSMEQT SLRSSRPSWT RSRSMASKLP 540
  541 REKMLVFVAG GTTFSELRTC YELSDKYNKD IYIGSTVCYS PNEWLDFFSK FQQPREALK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	175.0
Match:	1epuA
Description:	Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SNARE binding	4.56428593085019	bayes_pls_golite062009
syntaxin binding	3.46044132736061	bayes_pls_golite062009
binding	2.7837022903231	bayes_pls_golite062009
protein binding	2.77285532000616	bayes_pls_golite062009
syntaxin-1 binding	0.269372794919901	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [600-693]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPEDKPRHIP CLEARPSPNR IQEQPNIDVP STRYENTSSS DAVSIHKDEK KSKGKSHKLG  60
   61 KLMMSSKKDK DKSKEKVPTY GTSDKKKKKR FGVF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.205	c.15.1	BRCT domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: