YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC776.08c
Organism:	Schizosaccharomyces pombe
Length:	1097 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC776.08c.

Description	E-value	Query Range	Subject Range
NOL6_MOUSE - Nucleolar protein 6 OS=Mus musculus GN=Nol6 PE=2 SV=2	1360.0	[0..2]	[1094..36]
NOL6 - nucleolar protein family 6 (RNA-associated)	1354.0	[0..1]	[1094..24]
gi\|34867149, gi\|... - gi\|34867149\|ref\|XP_232898.2\| PREDICTED: similar to nucleolar RNA-associated protein alpha [Rattus no...	1344.0	[0..1]	[1094..26]
gi\|109111214 - gi\|109111214\|ref\|XP_001099208.1\| PREDICTED: similar to nucleolar RNA-associated protein alpha isofor...	1332.0	[0..1]	[1094..24]
gi\|73971747 - gi\|73971747\|ref\|XP_538704.2\| PREDICTED: similar to nucleolar RNA-associated protein alpha isoform [C...	1299.0	[0..19]	[1094..180]
gi\|67525995, gi\|... - gi\|67525995\|ref\|XP_661059.1\| hypothetical protein AN3455.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	1258.0	[0..11]	[1096..23]

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Predicted Domain #1

Region A:
Residues: [1-676]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGLKREHES SSSQDGSKTP ETEYDSHVDS IEDIHSLASK RKKLNEKKEN LEDLTLLKTS  60
   61 AFELKLNELI REISVRGKYF RHANTFVEKI KDLIFKTPVI PETNFWSACK NLEKDKKVIV 120
  121 PLAEPLSAKD TNLRASFVPP KTVTPGIFSC SNKFFLNPDG WSYDLFLEIP ESIFTQKDYL 180
  181 NGRYFRKRAF YLTCIAKHLL ENLGNEVKLE FVAFNDDIRR PILAILPESK GFAATGKRFT 240
  241 VFLIPTVRQI FPVSKLLPHK NAIRDFMEHE ELKPTPFYNN SVLEEQNLLF YRDLVKKYSV 300
  301 NPQFLDACGL GSTWLNMRGF SSSIHSNGFG LLEWYVLMAL LMSSTGLPAG NVLNTYLTAA 360
  361 QFFKSMLQFL SSKNLTSTLF KLNADSSNLK IGNGHLPTLI DCNTGFNLLG KMKQSFFEYF 420
  421 QASCRHTLNL LDENANYNFS KIFITHVNVP ALEFDVSGCI PLEPKELEDP NFCRKTDLDS 480
  481 PYSLYLEYTW DLLQHALGDR VCQIILYSSI CTSCSINESL KTKLPKLISF GLLLNPDALL 540
  541 RLVDIGPSPD DTVGSQKFRE FWGEVSELRK FKNGSIAESV YWECSSPDER IRIPQRIIRH 600
  601 ILNRHLGNNV GDRVSFRNEK FRVYVHSKIS PNTDTYNEYV PVMEAYNEAV KSLINLSDIP 660
  661 LSIAEILPAD ESLRYS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.55
Match:	1q78A
Description:	Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	3.21555027517466	bayes_pls_golite062009
nucleotidyltransferase activity	1.7166207083291	bayes_pls_golite062009
nucleic acid binding	1.4031460115872	bayes_pls_golite062009
polynucleotide adenylyltransferase activity	0.986864608285919	bayes_pls_golite062009
binding	0.940725834840942	bayes_pls_golite062009
DNA binding	0.931982952649779	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.825883515331479	bayes_pls_golite062009
catalytic activity	0.718799603354138	bayes_pls_golite062009
transferase activity	0.245732860673913	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [677-856]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSVPFYESS TCAPIDVVFQ FESSSKWPDE LEGIQRTKIA FLLKIAELLE ALDNVERASV  60
   61 GLENTDNPTH NCCFLQVLFS NNFTFRYRLR NDREIFFWKS LERNPSTKLS AQKGLYAYEH 120
  121 MFQFIPRHTL AIQAICQAHR SYSMAVRLAK HWFYSHLLTD HVTDEVIELL VASVYINSSS 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [857-1002]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WRTTSSGETS FCRMLHFLAH WDWRFDPLII NSNGKLPHDV RHQATEKLES IRKQDVAIAH  60
   61 NAYYIITDYD FDGNHIGYYK PSKIIANRIT SLARASLSEL LKDTPNYKSI FKSSLDIYHV 120
  121 VIDVNINKLP MYRESNLTKY KNLQNM

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.414	0.675	ribosome biogenesis	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.319	0.002	ribosome biogenesis	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.407	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.239	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.237	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains

Predicted Domain #4

Region A:
Residues: [1003-1097]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSERPGFEPI TEFVKELHRC FEDTISFFYN KKNPKVVTGV FNPRILANRP YRTNIDYPFK  60
   61 VVDKDTVVLD ADVVCEEIRQ VGGDLIRSIQ LQLKA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.557	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.545	d.58.10	Acylphosphatase-like
View	Download	0.630	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.503	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.622	d.50.2	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: