YRC Public Data Repository - Protein Structure Prediction

Protein:	cys11
Organism:	Schizosaccharomyces pombe
Length:	351 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cys11.

Description	E-value	Query Range	Subject Range
gi\|70985236, gi\|... - gi\|70985236\|ref\|XP_748124.1\| cysteine synthase (o-acetylserine (thiol)-lyase) (csase) [Aspergillus f... gi\|159125953 - gi\|159125953\|gb\|EDP51069.1\| cysteine synthase (o-acetylserine (thiol)-lyase) (csase) [Aspergillus fu...	337.0	[0..2]	[351..19]
gi\|114188610, gi... - gi\|115437378\|ref\|XP_001217795.1\| cysteine synthase [Aspergillus terreus NIH2624], gi\|114188610\|gb\|EA...	336.0	[0..15]	[351..35]
gi\|119182864, gi... - gi\|90301320\|gb\|EAS30951.1\| hypothetical protein CIMG_06430 [Coccidioides immitis RS], gi\|119182864\|r... gi\|240109424 - gi\|240109424\|gb\|EER27593.1\| cysteine synthase, putative [Coccidioides posadasii C735 delta SOWgp]	336.0	[0..11]	[351..38]
gi\|46097595, gi\|... - gi\|71024525\|ref\|XP_762492.1\| hypothetical protein UM06345.1 [Ustilago maydis 521], ref\|XP_403960.1\| ...	336.0	[0..2]	[351..28]
CYSK_EMENI - Cysteine synthase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139... CYSK_EMENI - Cysteine synthase OS=Emericella nidulans GN=cysB PE=3 SV=2	335.0	[0..15]	[351..34]
gi\|83771220 - gi\|83771220\|dbj\|BAE61352.1\| unnamed protein product [Aspergillus oryzae] gi\|169776037 - gi\|169776037\|ref\|XP_001822485.1\| hypothetical protein [Aspergillus oryzae RIB40]	334.0	[0..11]	[351..31]
CYSK_EMENI - Cysteine synthase (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase...	333.0	[0..21]	[351..41]
gi\|39977127, gi\|... - gi\|39977127\|ref\|XP_369951.1\| cysteine synthase [Magnaporthe grisea 70-15], gb\|EAA56495.1\| hypothetic...	331.0	[0..11]	[351..35]
gi\|46125819, gi\|... - gi\|46125819\|ref\|XP_387463.1\| CYSK_EMENI Cysteine synthase (O-acetylserine sulfhydrylase) (O-acetylse...	330.0	[0..15]	[351..35]
gi\|49656733 - gi\|49656733\|emb\|CAG89440.1\| DEHA2F16236p [Debaryomyces hansenii] gi\|49656733, gi\|... - gi\|50424945\|ref\|XP_461064.1\| hypothetical protein DEHA0F17534g [Debaryomyces hansenii CBS767], gi\|49...	329.0	[0..19]	[350..32]

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Predicted Domain #1

Region A:
Residues: [1-351]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATSGIQTKV PGIVSGFIGA IGRTPLIRLN TLSNETGCNI LAKAEFQNPG GSVKDRAAYY  60
   61 VVRDAEKKGK LSRGGTIVEG TAGNTGIGLA HIARARGYKC VIYMPNTQSQ AKIDTLKFLG 120
  121 AEVHPVPVAP FSNPLNYNHQ ARRHAESTPN ASWTDQFDNV ANLLSHYETT GPEIWDQTKG 180
  181 TVDGFTCSTG TGGTFAGVTK YLKEKSDGRV ASFVADPPGS VLYSHIKTKG KHPDNKGSSF 240
  241 TEGIGQGRIT GNVQPVYDLI DDAMKIPDEK SINMFFRLLD QEGLFLGGSS CLNVVAAVEM 300
  301 AKILGPGKTV VTILCDSGHK YATRLFSRSF LESKKLFDVI EPQYKKYIVL P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.0
Match:	1jbqA
Description:	Cystathionine beta-synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cysteine synthase activity	5.18562032111987	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
cystathionine beta-synthase activity	1.4517088142802	bayes_pls_golite062009
tryptophan synthase activity	1.04832999357666	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
threonine synthase activity	0.727838845253199	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: