YRC Public Data Repository - Protein Structure Prediction

Protein:	tlg1
Organism:	Schizosaccharomyces pombe
Length:	225 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tlg1.

Description	E-value	Query Range	Subject Range
gi\|109099266 - gi\|109099266\|ref\|XP_001111568.1\| PREDICTED: similar to syntaxin 2 isoform 2 [Macaca mulatta]	145.0	[0..9]	[224..131]
gi\|73958357 - gi\|73958357\|ref\|XP_547038.2\| PREDICTED: similar to Syntaxin-1B2 (Syntaxin 1B) (P35B) [Canis familiar...	138.0	[0..3]	[204..38]
gi\|220777, gi\|285304 - pir\|\|A38141 neuronal cell membrane antigen HPC-1 - rat (fragment), gi\|220777\|dbj\|BAA01231.1\| HPC-1 ...	132.0	[0..3]	[220..41]
gi\|531458, gi\|74... - gi\|7447071\|pir\|\|G01485 syntaxin - human, gi\|531458\|gb\|AAA20940.1\| syntaxin [Homo sapiens]	128.0	[0..3]	[220..2]
gi\|114613937 - gi\|114613937\|ref\|XP_001146812.1\| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]	127.0	[0..3]	[220..31]
gi\|50759625 - gi\|50759625\|ref\|XP_417710.1\| PREDICTED: similar to guanylate binding protein [Gallus gallus]	127.0	[0..12]	[224..1097]

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Predicted Domain #1

Region A:
Residues: [1-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDPFYEVKA DASNQMEQVR KLYNSFMAAR NSGVLSPNTE LTYAIDELSE TLKDLKAAVE  60
   61 IAMKNSEHFG LDEEELKSRR RFVSELDIEL NNIQLKMGAA PSTPVSTEPY TVDNGASAGL 120
  121 SEEDHAVNRQ YQEQLYQQQD VMLDGVYDTI GNIRGQAALM GEELGQQADL LDTLDNSIET 180
  181 TNSKLRRGMK RLKDFTIASA DSKSGCCITV LIIILIALLV LVIVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.522879
Match:	1dn1B
Description:	Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SNAP receptor activity	3.50393203740159	bayes_pls_golite062009
protein transporter activity	2.305772311362	bayes_pls_golite062009
binding	2.18404492932496	bayes_pls_golite062009
protein binding	1.82422117934251	bayes_pls_golite062009
phosphatidic acid binding	1.79882292156155	bayes_pls_golite062009
transporter activity	1.74189664015129	bayes_pls_golite062009
substrate-specific transporter activity	1.2360389745429	bayes_pls_golite062009
transmembrane transporter activity	1.13101548288086	bayes_pls_golite062009
SNARE binding	0.71459772253941	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.398018181744571	bayes_pls_golite062009
ion transmembrane transporter activity	0.0981818568206971	bayes_pls_golite062009
phospholipid binding	0.0172309833091902	bayes_pls_golite062009
cytoskeletal protein binding	0.00476738027966683	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: