YRC Public Data Repository - Protein Structure Prediction

Protein:	tlg2
Organism:	Schizosaccharomyces pombe
Length:	301 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tlg2.

Description	E-value	Query Range	Subject Range
gi\|109099266 - gi\|109099266\|ref\|XP_001111568.1\| PREDICTED: similar to syntaxin 2 isoform 2 [Macaca mulatta]	193.0	[0..62]	[299..131]
gi\|73958357 - gi\|73958357\|ref\|XP_547038.2\| PREDICTED: similar to Syntaxin-1B2 (Syntaxin 1B) (P35B) [Canis familiar...	185.0	[0..36]	[277..18]
gi\|50759625 - gi\|50759625\|ref\|XP_417710.1\| PREDICTED: similar to guanylate binding protein [Gallus gallus]	177.0	[0..55]	[297..1064]
gi\|118404044, gi... - gi\|118404044\|ref\|NP_001072191.1\| syntaxin 1A (brain) [Xenopus (Silurana) tropicalis], gi\|110645670\|g...	176.0	[0..30]	[298..3]
gi\|47222870 - gi\|47222870\|emb\|CAF96537.1\| unnamed protein product [Tetraodon nigroviridis]	175.0	[0..1]	[278..1]
gi\|220777, gi\|285304 - pir\|\|A38141 neuronal cell membrane antigen HPC-1 - rat (fragment), gi\|220777\|dbj\|BAA01231.1\| HPC-1 ...	175.0	[0..25]	[298..8]
gi\|303605 - gi\|303605\|dbj\|BAA03436.1\| epimorphin [Homo sapiens]	173.0	[0..30]	[299..3]

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Predicted Domain #1

Region A:
Residues: [1-301]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYRDRTGLY ITFRQSYSHH GQRLELSGWD PKEERQSLVH KDNKDNTVIE MDMLAPRWVT  60
   61 VEGEIDSLLL NTRRNINLLD KQYAKHVLPS FSDKTEQENE IQRLTIQITQ DFQRCQKLLQ 120
  121 VTKAQTNSAT GSEALMAKNF LSNLASRIQT ESAQFRKKQS TYLKKLRGLN ANISPVESKL 180
  181 DETVSDVAIS QSTIQQVALM EEQGEDEQAI RHERAVAKIA EGIIELAQMF QDLQVLVIEQ 240
  241 GALVDRIDFN IEQTQVHAKS AEKELIKAES HQKNTGRLRF ICFLILLIVA LIVILAIKLL 300
  301 R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.69897
Match:	1dn1B
Description:	Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SNAP receptor activity	2.83778981988519	bayes_pls_golite062009
binding	1.88170908543488	bayes_pls_golite062009
protein binding	1.29784552353214	bayes_pls_golite062009
SNARE binding	0.84282617892253	bayes_pls_golite062009
transporter activity	0.487715383686856	bayes_pls_golite062009
substrate-specific transporter activity	0.0443963926233321	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: