YRC Public Data Repository - Protein Structure Prediction

Protein:	mde4
Organism:	Schizosaccharomyces pombe
Length:	421 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mde4.

Description	E-value	Query Range	Subject Range
KRT84 - keratin 84	144.0	[0..2]	[267..232]
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	136.0	[0..14]	[379..2379]
gi\|109096767 - gi\|109096767\|ref\|XP_001093322.1\| PREDICTED: similar to keratin, hair, basic, 3 [Macaca mulatta]	131.0	[0..5]	[267..181]
gi\|4103156 - gi\|4103156\|gb\|AAD01692.1\| hair keratin basic 5; keratin Hb5 [Mus musculus]	131.0	[0..5]	[267..193]
gi\|114625886 - gi\|114625886\|ref\|XP_520149.2\| PREDICTED: similar to OTTHUMP00000021786 [Pan troglodytes]	129.0	[0..4]	[267..439]
gi\|115496498, gi... - gi\|76617959\|ref\|XP_606882.2\| PREDICTED: similar to keratin, hair, basic, 5 [Bos taurus], gi\|11549649...	124.0	[0..5]	[267..193]
gi\|73996366 - gi\|73996366\|ref\|XP_860589.1\| PREDICTED: similar to type II keratin Kb21 isoform 3 [Canis familiaris]	124.0	[0..29]	[267..160]

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Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTISTSTDS KLDNLGLSVT SRRNQILFYL SKALNLAHLL RSDSLQKSFL DALKQSATDS  60
   61 ELLHKNLDEI KFLQNEKLNN EKLLEQEQNE ANDYRLKVER LEHKISDYVQ EINSLNSQLQ 120
  121 IQKSNPEKHE DAVSQNRLRG SLDTVSSPSK THKANKDEKA TRLHLIIANL KKALKEKDAE 180
  181 VLNLQSHVSS KESELDRFKI KLETEESNWK VRLQVLESKL ATQDRKLRMQ KKSTERKSLL 240
  241 VSPRVSSPKL FSPSKQAIMG TRQPNATSGS PLSVTPFLQK TSTSIGLSSS PPQSSPSAQS 300
  301 SQPFSRDKYP HSMTVSPSNA RYLKKHLDDT IPSNVSDI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.30103
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [339-421]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHNDHLKIPQ SPSSLSPSKI PIRKKRKLKD TVSNCEFTEE DSESSFLLET IQPTKSTLRR  60
   61 SISPLKKRND EINELKKGFT MKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.341	a.5.2	UBA-like
View	Download	0.362	d.52.1	Alpha-lytic protease prodomain
View	Download	0.377	d.58.49	YajQ-like
View	Download	0.370	a.159.2	FF domain
View	Download	0.364	d.58.49	YajQ-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits