YRC Public Data Repository - Protein Structure Prediction

Protein:	iah1
Organism:	Schizosaccharomyces pombe
Length:	246 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for iah1.

Description	E-value	Query Range	Subject Range
gi\|114576028 - gi\|114576028\|ref\|XP_001155422.1\| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes] IAH1 - isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	178.0	[0..23]	[243..1]
gi\|109101965 - gi\|109101965\|ref\|XP_001084501.1\| PREDICTED: hypothetical protein isoform 2 [Macaca mulatta]	177.0	[0..23]	[243..1]
IAH1_RAT - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Rattus norvegicus GN=Iah1 PE=2 SV=2	173.0	[0..23]	[243..1]
IAH1_MOUSE - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Mus musculus GN=Iah1 PE=1 SV=1	173.0	[0..23]	[243..1]
IAH1_BOVIN - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus GN=IAH1 PE=2 SV=1	172.0	[0..23]	[243..1]
gi\|73980321 - gi\|73980321\|ref\|XP_852049.1\| PREDICTED: hypothetical protein XP_846956 [Canis familiaris]	171.0	[0..23]	[243..1]
gi\|50745011 - gi\|50745011\|ref\|XP_419943.1\| PREDICTED: similar to hypothetical protein 4833421E05Rik [Gallus gallus...	162.0	[0..20]	[243..64]
gi\|215697763, gi... - gi\|78708813\|gb\|ABB47788.1\| GDSL-like Lipase/Acylhydrolase family protein, expressed [Oryza sativa (j...	154.0	[0..19]	[243..16]
gi\|63101440 - gi\|63101440\|gb\|AAH95279.1\| Iah1 protein [Danio rerio]	153.0	[0..14]	[243..9]
gi\|114576030 - gi\|114576030\|ref\|XP_001155356.1\| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes] gi\|119621391 - gi\|119621391\|gb\|EAX00986.1\| hCG1685787, isoform CRA_c [Homo sapiens]	152.0	[0..48]	[243..1]

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Predicted Domain #1

Region A:
Residues: [1-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSQDKNYI SFEKTEIGQI VSEAPAEKYV SFQKKYFNRL TIIGDSITQK GFTPGGYCAE  60
   61 LMNFYQRRLR VDVWGFSGYT SRHVLRYLPE IPLEIDSTKL LIVFLGTNDC QLTETGYMCP 120
  121 VDEFKNNLLA LTRPFPHSKI IIVSPGICTK DICFKREQEP YVIAASETVN TLNKSKANSA 180
  181 GLINLYEITK SYPTPELLFT DGLHFSSLGY SLLFNEIVAT ISKAWPELLP NNLPLQFPHW 240
  241 SEILFT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.69897
Match:	1yzfA
Description:	Crystal structure of the lipase/acylhydrolase from Enterococcus faecalis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.15974340242656	bayes_pls_golite062009
hydrolase activity	0.755660272658182	bayes_pls_golite062009
binding	0.723787843954977	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.39017969987234	bayes_pls_golite062009
protein binding	0.289427729451854	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: