YRC Public Data Repository - Protein Structure Prediction

Protein:	trp3
Organism:	Schizosaccharomyces pombe
Length:	489 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trp3.

Description	E-value	Query Range	Subject Range
gi\|48845511, gi\|... - gi\|78223698\|ref\|YP_385445.1\| anthranilate synthase, component I [Geobacter metallireducens GS-15], g...	578.0	[0..4]	[479..3]
gi\|53765249, gi\|... - gi\|75910917\|ref\|YP_325213.1\| anthranilate synthase, component I [Anabaena variabilis ATCC 29413], gi...	575.0	[0..3]	[475..2]
gi\|17227824, gi\|... - gi\|17227824\|ref\|NP_484372.1\| anthranilate synthase component I [Nostoc sp. PCC 7120], gi\|17129673\|db... gi\|25291358 - pir\|\|AG1847 anthranilate synthetase alpha-chain [imported] - Nostoc sp. (strain PCC 7120)	574.0	[0..3]	[475..2]
gi\|39997478, gi\|... - gi\|39997478\|ref\|NP_953429.1\| anthranilate synthase component I [Geobacter sulfurreducens PCA], gi\|39...	567.0	[0..4]	[479..3]
gi\|88936974, gi\|... - gi\|88936974\|ref\|ZP_01142564.1\| Anthranilate synthase component I [Geobacter uraniumreducens Rf4], gi...	566.0	[0..4]	[479..3]
gi\|69255802, gi\|... - gi\|69255802\|ref\|ZP_00605544.1\| Anthranilate synthase component I [Magnetococcus sp. MC-1], gi\|682481...	562.0	[0..3]	[482..2]
gi\|73660864, gi\|... - gi\|73749148\|ref\|YP_308387.1\| anthranilate synthase component I [Dehalococcoides sp. CBDB1], gi\|73660...	562.0	[0..4]	[478..3]
gi\|110599895, gi... - gi\|222056522\|ref\|YP_002538884.1\| anthranilate synthase component I [Geobacter sp. FRC-32], gi\|221565...	562.0	[0..4]	[478..3]
gi\|186685226, gi... - gi\|23128201\|ref\|ZP_00110054.1\| COG0147: Anthranilate/para-aminobenzoate synthases component I [Nosto...	561.0	[0..3]	[475..2]
gi\|57233826, gi\|... - gi\|57233826\|ref\|YP_182181.1\| anthranilate synthase component I [Dehalococcoides ethenogenes 195], gi...	560.0	[0..4]	[478..3]

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Predicted Domain #1

Region A:
Residues: [1-489]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIYPDLKQV QELAEKHKAN KIPIYGVIPA DMLTPSVAYL KLNQGKKYSF ILESVTQGES  60
   61 VSRYSFIGSP YRILMANGKT DPLARLEREL KEVKTAPVEG LPSFSGGAVG YVSYDCIKYF 120
  121 EPTTEMPLED TLGLPEAMFF MTDDLVAFDH AYQTVKIISH VCIQQGRPIE EAYEAAVFKI 180
  181 NMLKKKLESP EIPLPEQKKV HLGYEAKSNV GEDGYKAFVS NLKEHIFNGD IFQAVPSQRI 240
  241 ARRTDLHPFN LYRHLRTVNP SPYMFYIHCD DFDIIGASPE LLVKSEHGRI INHPIAGTVP 300
  301 RGKTKEEDEA YAKDLLASVK DRAEHVMLVD LARNDVSRVC DLDTTSVDKL MTIEKFSHVQ 360
  361 HLVSQVSGVL RPDKTRFDAF RSIFPAGTVS GSPKVRAIQL VYGLEKEKRG IYAGAVGRWG 420
  421 YEDDNMDTCI AIRTMVYKDG TVYLQAGGGI VFDSDEQDEY VETLNKLRSN VTAIEETEKL 480
  481 YAEEENSSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	124.0
Match:	1i1qA
Description:	Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit, TrpE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anthranilate synthase activity	11.4918303265177	bayes_pls_golite062009
4-amino-4-deoxychorismate synthase activity	9.91522831720207	bayes_pls_golite062009
oxo-acid-lyase activity	9.57649905871948	bayes_pls_golite062009
carbon-carbon lyase activity	2.42362294309332	bayes_pls_golite062009
catalytic activity	2.11110806828104	bayes_pls_golite062009
binding	1.73874372115438	bayes_pls_golite062009
lyase activity	0.454734323696838	bayes_pls_golite062009
protein binding	0.323833479841771	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: