YRC Public Data Repository - Protein Structure Prediction

Protein:	sec61
Organism:	Schizosaccharomyces pombe
Length:	479 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sec61.

Description	E-value	Query Range	Subject Range
gi\|109088214 - gi\|109088214\|ref\|XP_001085071.1\| PREDICTED: similar to dehydrogenase E1 and transketolase domain con...	498.0	[0..3]	[465..1012]
gi\|119182304, gi... - gi\|90301081\|gb\|EAS30712.1\| protein transport protein SEC61 alpha subunit [Coccidioides immitis RS], ... gi\|240109234 - gi\|240109234\|gb\|EER27403.1\| Protein transport protein SEC61 alpha subunit, putative [Coccidioides po...	446.0	[0..1]	[464..1]
gi\|114589143 - gi\|114589143\|ref\|XP_516725.2\| PREDICTED: similar to sec61-like protein [Pan troglodytes]	446.0	[0..4]	[465..114]
gi\|40742046, gi\|... - gi\|67901468\|ref\|XP_680990.1\| hypothetical protein AN7721.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	445.0	[0..1]	[464..1]
gi\|73949146 - gi\|73949146\|ref\|XP_535191.2\| PREDICTED: similar to Sec61, alpha subunit 2 [Canis familiaris]	445.0	[0..4]	[465..78]
gi\|169778131 - gi\|169778131\|ref\|XP_001823531.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|220695586, gi... - gi\|238495400\|ref\|XP_002378936.1\| protein transport protein Sec61 alpha subunit, putative [Aspergillu... gi\|83772268 - gi\|83772268\|dbj\|BAE62398.1\| unnamed protein product [Aspergillus oryzae]	444.0	[0..1]	[464..1]
gi\|70998192, gi\|... - gi\|70998192\|ref\|XP_753823.1\| protein transport protein Sec61 alpha subunit [Aspergillus fumigatus Af... gi\|159126440 - gi\|159126440\|gb\|EDP51556.1\| protein transport protein Sec61 alpha subunit, putative [Aspergillus fum...	443.0	[0..1]	[464..1]
gi\|115433596, gi... - gi\|115433596\|ref\|XP_001216935.1\| protein transport protein SEC61 alpha subunit [Aspergillus terreus ...	443.0	[0..1]	[464..1]
gi\|50754395 - gi\|50754395\|ref\|XP_414364.1\| PREDICTED: similar to Sec61 alpha subunit homolog [Gallus gallus]	441.0	[0..4]	[465..164]

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Predicted Domain #1

Region A:
Residues: [1-479]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLRFLDLV KPFAPFLPEI AAPERKVPFK QKMLWTGVTL LIFLVMSQVP LYGIVSSDSS  60
   61 DPLLWLRMIL AANRGTLMEL GISPIVTSSM LVQLLVGSQL IEVNMELKSD REMYQLVQKF 120
  121 LAIIIAFGQA TAYVLTGMYG RPQDLGAGIC LLLILQLAAA SLIVLLLDEL LQKGYGLGSG 180
  181 ISLFIATINC ENIFWKAFSP TTYHIANGVQ FEGAVINFVY VMFTWDNKAA ALYQAFFRSG 240
  241 LTSSQIQLPN LWNFFATLLV FGVVIYLQDF RVEIPIRSQK FRGYRSTFPV KLLYTSNTPI 300
  301 MLQSALTSNL FFASRLLFNR FSSNFLVRFL GVWEQTATSG LSYYLSPPAS FQDALIDPIH 360
  361 TLVYVFFTMF ACALFSKLWI EVSGASPRDV AKQLKSQQLV MAGHREGSMY KELKRIIPTA 420
  421 AWLSGAVVGA LAVASDLLGA LGSGTAVLLC TTTIYGYYEQ LQKEIKGDQY GLPVTPMMQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.522879
Match:	1rh5A
Description:	The structure of a protein conducting channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonucleoprotein binding	5.96221631042313	bayes_pls_golite062009
protein transporter activity	5.55929343005534	bayes_pls_golite062009
transporter activity	3.32223562584466	bayes_pls_golite062009
substrate-specific transporter activity	3.22714325269757	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	2.12732472524264	bayes_pls_golite062009
macromolecule transmembrane transporter activity	2.12732472524264	bayes_pls_golite062009
protein transmembrane transporter activity	1.76187269823414	bayes_pls_golite062009
transmembrane transporter activity	1.67782980643723	bayes_pls_golite062009
binding	1.4562802789412	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.42890247609405	bayes_pls_golite062009
primary active transmembrane transporter activity	1.15847548838424	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.15316743403707	bayes_pls_golite062009
active transmembrane transporter activity	1.10003802565492	bayes_pls_golite062009
peptide transporter activity	1.01893828721893	bayes_pls_golite062009
protein binding	0.674651002700028	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: