YRC Public Data Repository - Protein Structure Prediction

Protein:	ade3
Organism:	Schizosaccharomyces pombe
Length:	1323 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ade3.

Description	E-value	Query Range	Subject Range
gi\|121629408, gi... - gi\|75815489\|ref\|ZP_00745995.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas...	1298.0	[0..1]	[1323..1]
gi\|125619740, gi... - gi\|75831918\|ref\|ZP_00761177.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas... gi\|146315234, gi... - gi\|75826192\|ref\|ZP_00755627.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas... PUR4_VIBCH - Phosphoribosylformylglycinamidine synthase OS=Vibrio cholerae GN=purL PE=3 SV=1 gi\|121550061, gi... - gi\|121585698\|ref\|ZP_01675493.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae 2740-80]... gi\|229371197, gi... - gi\|229608542\|ref\|YP_002879190.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosp... gi\|124117863, gi... - gi\|153224103\|ref\|ZP_01954227.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae MAK 757]... gi\|229517927, gi... - gi\|229517927\|ref\|ZP_04407371.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... PUR4_VIBCH - Phosphoribosylformylglycinamidine synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El To... gi\|153819005, gi... - gi\|153819005\|ref\|ZP_01971672.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae NCTC 845... gi\|229357746, gi... - gi\|229505523\|ref\|ZP_04395033.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... gi\|229510807, gi... - gi\|229510807\|ref\|ZP_04400286.1\| phosphoribosylformylglycinamidine synthase synthetase subunit/phosph... gi\|227081045, gi... - gi\|227081045\|ref\|YP_002809596.1\| phosphoribosylformylglycinamidine synthase [Vibrio cholerae M66-2],...	1297.0	[0..1]	[1323..1]
gi\|194537878, gi... - gi\|75819598\|ref\|ZP_00749670.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas...	1292.0	[0..1]	[1323..1]
gi\|91225083, gi\|... - gi\|91225083\|ref\|ZP_01260305.1\| phosphoribosylformylglycinamidine synthase [Vibrio alginolyticus 12G0...	1286.0	[0..1]	[1323..1]
gi\|75855043, gi\|... - gi\|75855043\|ref\|ZP_00762707.1\| COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetas...	1285.0	[0..1]	[1323..1]
PUR4_VIBPA - Phosphoribosylformylglycinamidine synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 22... gi\|149748904, gi... - gi\|153837709\|ref\|ZP_01990376.1\| phosphoribosylformylglycinamidine synthase [Vibrio parahaemolyticus ... PUR4_VIBPA - Phosphoribosylformylglycinamidine synthase OS=Vibrio parahaemolyticus GN=purL PE=3 SV=1	1283.0	[0..1]	[1323..1]
gi\|110616035, gi... - gi\|110806487\|ref\|YP_690007.1\| phosphoribosylformylglycinamidine synthase [Shigella flexneri 5 str. 8... gi\|24052983, gi\|... - ref\|NP_708394.1\| phosphoribosylformyl-glycineamide synthetase [Shigella flexneri 2a str. 301], gb\|A...	1281.0	[0..1]	[1323..54]
gi\|37197773, gi\|... - gi\|37679031\|ref\|NP_933640.1\| phosphoribosylformylglycinamidine synthase [Vibrio vulnificus YJ016], g...	1281.0	[0..1]	[1322..55]
lcl\|NC_016856.1_... - [gene=purG] [protein=phosphoribosylformylglycinamidine synthase] [protein_id=YP_005238672.1] [locati... PUR4_SALTY - Phosphoribosylformylglycinamidine synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7... PUR4_SALTY - Phosphoribosylformylglycinamidine synthase OS=Salmonella typhimurium GN=purL PE=1 SV=3 PUR4_SALTY - Phosphoribosylformylglycinamidine synthase OS=Salmonella typhimurium GN=purL PE=1 SV=3 gi\|205329118, gi... - gi\|205357853\|ref\|ZP_02573792.2\| phosphoribosylformylglycinamidine synthase [Salmonella enterica subs...	1281.0	[0..1]	[1323..2]
PUR4_SHISS - Phosphoribosylformylglycinamidine synthase OS=Shigella sonnei (strain Ss046) GN=purL PE=3 SV=3	1280.0	[0..1]	[1323..2]

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Predicted Domain #1

Region A:
Residues: [1-1323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVYYGGSAL SVQSKKKILE LTVSGVSDLN AVYFYLIYTK SNSSLNCESL RPILSDLQES  60
   61 EFKPDGTTMV YVFPRPGTIS PWSSKATNIA NVCGYKDVIR IERGIAYSVV FKDDISEEML 120
  121 KSALNHLYDR MTEALRFKLP EEDEVFDKHE PAPLVRIELN CGQGGDKQAA TERLNHANKK 180
  181 FGLALAPDEI DYLVECYTSE PSLKSREPTD VELFMFGQVN SEHCRHKIFN ADWTIDGEKK 240
  241 DYSLFKMIRN THLKNPQYTI SAYSDNAAVF EGNSGTLFAP VNGIWSMKDE PVEFLGKVET 300
  301 HNHPTAVSPF PGAATGSGGE IRDEGAVGQG SLSKAGLAGY SVSDLNIPGY KQPWELDVGK 360
  361 PYHIATSLDI MLEAPIGSSA FNNEFGRPCI NGYFRTFCME VPRGDGTLEI RGYHKPIMAA 420
  421 GGIGRIRKQH AFKKSIAPGS PIIVLGGPAL LVGLGGGAAS SMNAGEGSEE LDFASVQRGN 480
  481 PEMQRRAQMV IDACTTMDEN IIQSIHDVGA GGVSNALPEL VHDAGLGARF ELRDIPCIEP 540
  541 SMSPMQIWCC ESQERYVLSV KSEDLDTFKS ICERERCPYG VVGYSTVEQR LILTDRLYNT 600
  601 TPIDLPMEVL FGKPPKMSRV AETQTIPLSK FDSSLKSYLA PSSDPILDAV ERVLRMPAVA 660
  661 SKSFLITIGD RSVTGLIARD QMVGPWQVPV ADVGVTVTSY GKGINTGEAL AMGEKPISAL 720
  721 VSAAASARMA VAECIMNLVA ASIPALDRIR LSANWMAAPS HPGEGAKLYE AVQAIGLELC 780
  781 PSLGISIPVG KDSMSMSMKW NEDGREKSVT APLSLIITGF SPVDDLYSIW TPQLRKVEDI 840
  841 GSTSLIFIDL ANGKQRLGGS ILAQSYKQLG DEVPDLDNLD TFKNFINVIT QLHKTNYIQA 900
  901 YHDKSDGGLF VTLSEMAFAG HVGIECELDS LSSDNIAALF NEELGAVIQV CDRDIAKVLE 960
  961 LFAANGLSTC VHRIGKVLSG QAQTISFSRS GKIIFKSTRS KLHGIWHETS YKMQEIRDNP1020
 1021 ECARQEMENI ADNNDPGLGY HLTFDPNVSV TADLALTSRP KVAILREQGV NGYLEMAYAF1080
 1081 YASGFTAVDV HMTDILSGRV HLDDFVGIAA CGGFSYGDVL GSGNGWATSI LLHEDARNEF1140
 1141 YRFFNERKDT FGLGICNGCQ LFSRLKSLIP GAKSWPMFTF NESAQYEGRA VMLKIDETSG1200
 1201 SKSIFTESMA GSSLPVVVAH GEGRAVFDSE SDYEQFKKEG LDLIYYVNNY NERTSRYPFN1260
 1261 PNGSRDAIAG VRSPCGRFLA MMPHPERVVL KVANSYYPHS KASEWGVHGP WIRLFQSARK1320
 1321 WVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1t3tA
Description:	Structure of Formylglycinamide synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosylformylglycinamidine cyclo-ligase activity	3.04322905277855	bayes_pls_golite062009
cyclo-ligase activity	2.40623349460413	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
binding	1.31749052462602	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.78656048097577	bayes_pls_golite062009
catalytic activity	0.317253455922165	bayes_pls_golite062009
protein binding	0.288540446972424	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	0.268823253442304	bayes_pls_golite062009
nucleic acid binding	0.12569720972861	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: