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View Structure Prediction Details

Protein: shk1
Organism: Schizosaccharomyces pombe
Length: 658 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shk1.

Description E-value Query
Range
Subject
Range
gi|2130467, gi|1... - pir||S60170 protein kinase Pak1 - fission yeast (Schizosaccharomyces pombe), gi|1586089|prf||220326...
403.0 [0..1] [658..1]
gi|25573205 - gi|25573205|gb|AAN75173.1| STE20 [Cryptococcus neoformans var. grubii]
374.0 [0..3] [656..4]
gi|54112194 - gi|54112194|gb|AAV28796.1| STE20p [Cryptococcus gattii]
gi|54112194 - gi|54112194|gb|AAV28796.1| STE20p [Cryptococcus gattii]
373.0 [0..3] [656..4]
gi|134088321, gi... - gi|50258679|gb|EAL21364.1| hypothetical protein CNBD0600 [Cryptococcus neoformans var. neoformans B-...
gi|58265924, gi|... - gi|58265924|ref|XP_570118.1| STE20 [Cryptococcus neoformans var. neoformans JEC21], gi|57226351|gb|A...
gi|12060949 - gi|12060949|gb|AAG48305.1|AF315635_1 STE20 [Cryptococcus neoformans var. neoformans]
368.0 [0..3] [651..4]
gi|182890286, gi... - gi|41152203|ref|NP_958485.1| p21-activated kinase 1 [Danio rerio], gi|28277471|gb|AAH44138.1| P21/Cd...
363.0 [0..53] [658..2]
gi|12060955 - gi|12060955|gb|AAG48308.1|AF315638_1 Ste20 a kinase [Filobasidiella neoformans]
353.0 [0..4] [656..6]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERGTLQPRK KAPNGYGITP IVAHKTGEPV RYEVEDDLRK LKPSRTAPKP PAINTNLAED  60
   61 TFSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [65-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPLSQSRTTV SRVSLGSRQH SSSSIRKLQT NVSDVRSYDE RNQKKSAFEN FVSSMSSFLT  60
   61 GGGSSPTSSY GSGSASPRKS TVISSPFDPK HVTHVGFNYD TGEFTGMPTE WQALLKVSGI 120
  121 TKSEQVQHPQ AVLDAMAFYS QSKKYLEEGA KPPFPRESTE KPLLSVSALS SSSHLQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.05
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [241-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTSATSSSSR LYPSRPAPTP PASSSSSPLL SSQTVKTTTS NASRQPSPLV SSKSTDNIIR  60
   61 SHSPVLLTPQ TLSTSETKHI RPNNSTPYQR RAETSTKPKA VATPQKVEAP SAPRLQKRAP 120
  121 RQQSNDSAVL AKLQSICNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [380-658]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNPTLLYRNF VKIGQGASGD VYSARQVGTN LSVAIKKMNI NQQPKKEFIV NEILVMKSHH  60
   61 HKNIVNFIDT FFYKSELWMV MEYMRGGSLT EVVTNNTLSE GQIAAICKET LEGLQHLHEN 120
  121 GIVHRDIKSD NILLSLQGDI KLTDFGFCAQ IDSNMTKRTT MVGTPYWMAP EVVTRKEYGF 180
  181 KVDVWSLGIM AIEMVEGEPP YLNENPLRAL YLIATIGTPK ISRPELLSSV FHDFLSKSLT 240
  241 VNPKQRPSSG ELLRHPFLKQ AVPVSSLIPL IKSIHHSGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.522879
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle