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View Structure Prediction Details

Protein: mex67
Organism: Schizosaccharomyces pombe
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mex67.

Description E-value Query
Range		 Subject
Range
NXF1_PONAB - Nuclear RNA export factor 1 OS=Pongo abelii GN=NXF1 PE=3 SV=1
NXF1_PONPY - Nuclear RNA export factor 1 - Pongo pygmaeus (Orangutan)
 258.0 [0..104] [595..139]
NXF1 - nuclear RNA export factor 1
gi|123999198, gi... - gi|123999198|gb|ABM87179.1| nuclear RNA export factor 1 [synthetic construct], gi|123988683|gb|ABM83...
gi|114638083 - gi|114638083|ref|XP_001157986.1| PREDICTED: nuclear RNA export factor 1 isoform 9 [Pan troglodytes]
 257.0 [0..104] [595..139]
gi|114638087 - gi|114638087|ref|XP_508503.2| PREDICTED: nuclear RNA export factor 1 isoform 10 [Pan troglodytes]
 257.0 [0..104] [595..135]
NXF1_RAT - Nuclear RNA export factor 1 OS=Rattus norvegicus GN=Nxf1 PE=2 SV=1
 255.0 [0..104] [595..138]
NXF1_MOUSE - Nuclear RNA export factor 1 OS=Mus musculus GN=Nxf1 PE=1 SV=2
 253.0 [0..104] [595..138]
gi|109105698 - gi|109105698|ref|XP_001115941.1| PREDICTED: similar to nuclear RNA export factor 1 isoform 1 [Macaca...
 252.0 [0..104] [595..135]
NXF1_BOVIN - Nuclear RNA export factor 1 OS=Bos taurus GN=NXF1 PE=2 SV=1
 252.0 [0..104] [595..140]

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Predicted Domain #1
Region A:
Residues: [1-303] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRRKRERRN AVKENEMVID TPLEKRRTPG KPRATREPPI SVVITGHSKG SEDDLISFVW  60
   61 RKVKVRLMNI SYSPASVTAV VKSQDFSRLN GLNGAAFAGD HLAIRRVDGA SNVTQDYRKA 120
  121 KTKRSFRSVS APSLSALATQ AQRNVSKTLP QSTNETIEKL RQFLQTRYQP ATKFLDLGNL 180
  181 QQDPLLKQMG ILAEASTKSK MFPALMKVAS LNFPDVISVS LSDNNLQSVT AVTTLAQTWP 240
  241 KLLNLSLANN RITSLSDLDP WSPKTKLPEL QELVLVGNPI VTTFANRAMD YQREMVSRFP 300
  301 KLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 1wwlA
Description: Crystal structure of CD14
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [304-486] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLDGNSINSE IIASQSTVPF PVYQSFFDKV ETEQIVNSFL AAFFKGWDEN RSALVNQLYS  60
   61 PNATFSISLN ASNVRTNFSQ KTDTKKWGAY KMKSRNLLYS QSQKESKSRL FNGHEEISNA 120
  121 VKSLPATAHD LSDRSQWVFD GWNLVLPSVG AAIKIVVHGQ FEEPQNKRLL RSFDRTLLIL 180
  181 PGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 1q40B
Description: Crystal structure of the C. albicans Mtr2-Mex67 M domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleocytoplasmic transporter activity 4.11811310168752 bayes_pls_golite062009
protein transporter activity 3.25560675565407 bayes_pls_golite062009
binding 2.52411158739487 bayes_pls_golite062009
protein transmembrane transporter activity 2.19585939185279 bayes_pls_golite062009
structural constituent of nuclear pore 2.18859566641856 bayes_pls_golite062009
nucleic acid binding 2.1539951593359 bayes_pls_golite062009
transporter activity 1.80701285041353 bayes_pls_golite062009
structural molecule activity 1.60851232976006 bayes_pls_golite062009
mRNA binding 1.48678274024408 bayes_pls_golite062009
protein binding 1.34243535208605 bayes_pls_golite062009
substrate-specific transporter activity 1.33804818542017 bayes_pls_golite062009
transmembrane transporter activity 1.22102896992563 bayes_pls_golite062009
Ran GTPase binding 1.18290069522408 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.890150150408175 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.77053580490303 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.77053580490303 bayes_pls_golite062009
RNA binding 0.47499792472996 bayes_pls_golite062009
primary active transmembrane transporter activity 0.446562877324676 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.439519001457896 bayes_pls_golite062009
active transmembrane transporter activity 0.430285640125175 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [487-596] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STGILIINDL LVIRSFAGSL GWLPGQSSVR TSNNAMSASA SKPSDIVQPR PEQAMLDTRQ  60
   61 QIVLKIKAET GLNDYYAHMC CEQNNWDYNS ALASFLELKS RNVIPAEAFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1jkgB
Description: NTF2-like domain of Tip associating protein, TAP
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle