YRC Public Data Repository - Protein Structure Prediction

Protein:	cys12
Organism:	Schizosaccharomyces pombe
Length:	395 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cys12.

Description	E-value	Query Range	Subject Range
TRPB_TRIEI - Tryptophan synthase beta chain OS=Trichodesmium erythraeum (strain IMS101) GN=trpB PE=3 SV=1	326.0	[0..4]	[371..18]
TRPB_HELPJ - Tryptophan synthase beta chain OS=Helicobacter pylori (strain J99 / ATCC 700824) GN=trpB PE=3 SV=1 gi\|7437012 - gi\|7437012\|pir\|\|C71836 tryptophan synthase beta chain - Helicobacter pylori (strain J99)	324.0	[0..3]	[374..4]
gi\|71739840, gi\|... - gi\|71839674\|ref\|ZP_00679418.1\| Tryptophan synthase, beta chain [Pelobacter propionicus DSM 2379], gi...	323.0	[0..2]	[371..6]
TRPB_THETN - Tryptophan synthase beta chain OS=Thermoanaerobacter tengcongensis GN=trpB PE=3 SV=1 TRPB_CALS4 - Tryptophan synthase beta chain OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 152...	323.0	[0..3]	[378..2]
gi\|86605059 - gi\|86605059\|ref\|YP_473822.1\| tryptophan synthase, beta subunit [Cyanobacteria bacterium Yellowstone ... gi\|86553601, gi\|... - gi\|86605059\|ref\|YP_473822.1\| tryptophan synthase subunit beta [Synechococcus sp. JA-3-3Ab], gi\|86553...	323.0	[0..3]	[372..6]
TRPB_HELPY - Tryptophan synthase beta chain OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=trpB PE=3 SV=1 TRPB_HELPY - Tryptophan synthase beta chain OS=Helicobacter pylori GN=trpB PE=3 SV=1	321.0	[0..2]	[374..3]
gi\|107837432, gi... - gi\|108563659\|ref\|YP_627975.1\| tryptophan synthase subunit beta [Helicobacter pylori HPAG1], gi\|10783...	320.0	[0..2]	[374..3]
gi\|145588957, gi... - gi\|145588957\|ref\|YP_001155554.1\| tryptophan synthase subunit beta [Polynucleobacter necessarius subs...	320.0	[0..2]	[371..7]
gi\|57157621 - gi\|57157621\|dbj\|BAD83779.1\| tryptophan synthase beta subunit [Polygonum tinctorium]	320.0	[0..4]	[370..83]
TRPB_CAMAC - Tryptophan synthase beta chain 2, chloroplastic OS=Camptotheca acuminata GN=TSB PE=2 SV=1	320.0	[0..4]	[370..75]

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Predicted Domain #1

Region A:
Residues: [1-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKYQDLAS GIAMGAVFMY LLRRLYESLR VKSSADSLEE DIVNGVEGLI GNTKMVRIKS  60
   61 LSQATGCDIL AKAEFLNPGN SPKDRVALQM IRTAEENGDL VPYQSNAVYE GTAGSTGISI 120
  121 AMLCCSLGYD SRIYMPSDQS KEKSDILELL GAHVQRVTPA PIVDPNHFVN TARRNAANHT 180
  181 VDESIPGKGY FANQFENPAN WQAHFNSTGP EIWRQCAGKL DAFIAGSGTG GTIAGISRYL 240
  241 KSKDPSITVC LADPPGSGLY HKVLHGVMFD LAEREGTRRR HQVDTIVEGV GINRMTRNFS 300
  301 IAEPLIDMAY RVTDEQAVAM SRYLVTHDGL FVGSSSAVNC VAAVRLAKKL GPGHRIVTLL 360
  361 CDPGSRHFSK LYNEEFLRKK NIVPQVPSSL DFVEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.69897
Match:	1jbqA
Description:	Cystathionine beta-synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cysteine synthase activity	5.18562032111987	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
cystathionine beta-synthase activity	1.4517088142802	bayes_pls_golite062009
tryptophan synthase activity	1.04832999357666	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
threonine synthase activity	0.727838845253199	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: