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View Structure Prediction Details

Protein: alp14
Organism: Schizosaccharomyces pombe
Length: 809 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alp14.

Description E-value Query
Range
Subject
Range
gi|114637397 - gi|114637397|ref|XP_001165504.1| PREDICTED: colonic and hepatic tumor over-expressed protein isoform...
373.0 [0..3] [683..1]
gi|73982470 - gi|73982470|ref|XP_850474.1| PREDICTED: similar to colonic and hepatic tumor over-expressed protein ...
372.0 [0..3] [683..1]
gi|66955862, gi|... - gi|66955862|ref|NP_083713.1| cytoskeleton associated protein 5 [Mus musculus], gi|66570894|gb|AAH964...
371.0 [0..3] [683..1]
gi|109470247 - gi|109470247|ref|XP_001068339.1| PREDICTED: similar to cytoskeleton associated protein 5 isoform 1 [...
370.0 [0..3] [683..1]
CKAP5 - cytoskeleton associated protein 5
369.0 [0..3] [683..1]

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Predicted Domain #1
Region A:
Residues: [1-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDQEEDYS KLPLESRIVH KVWKVRLSAY EECSKSFSLS ADGSDNCFEL WNNQSELWKS  60
   61 VLTDSNVAAQ EAGTAAFVAY CRFSDPSHLL KAREISVLSI SEKCLTSPRA GTRENALEAL 120
  121 MLLVEADSAA PVIESIIPSL SARSPKVIAS NVAAIASLVE QFGAKVIPSK MIIPHISNLF 180
  181 GHADKNVRKE ASRLTVNIYR WTGDPLKDLL FKDLRPVQTK ELESLFAELP TEPPKQTRFL 240
  241 KSQQPTSEPN VETQVEEQPA LENEESEPEP SDDQFDLVEE VDVLPNVDPN LETLMASSKW 300
  301 KDRKEALDKL LPVLSQPKIK DNDFFNLVAI LTKSVSKDAN IMVVINAAHC IQAMAKGLRS 360
  361 NFSKYASTSI NALLERSKEK KANVIESLSS AMDAVLATSS LDDLAELIAS FAGNKNPQIK 420
  421 SSCFSLFSRS FSNMTSLPSK FTVDTCAKAC VPGVSDTFEP VRSAAAEALG VLMKLVGERA 480
  481 INQYLSPLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.39794
Match: 1qbkB
Description: Karyopherin beta2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.05338750264476 bayes_pls_golite062009
binding 2.6374633159018 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
transporter activity 1.55621630624352 bayes_pls_golite062009
substrate-specific transporter activity 1.33334123659384 bayes_pls_golite062009
protein transmembrane transporter activity 1.15447282085461 bayes_pls_golite062009
transmembrane transporter activity 0.350388174853674 bayes_pls_golite062009
nucleic acid binding 0.345785895390889 bayes_pls_golite062009
signal sequence binding 0.27824906981293 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.141331164449492 bayes_pls_golite062009
RNA binding 0.0287526191298597 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [490-640]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIRKSKIRSF YETATVKAKA PTKKSKVKPS KQEESKVVVP SNAKAVKKSV VPSSPVVPSP  60
   61 RKATNKSLSM DVSKGNAFEN GPLLPRPTTR PVSRGLSRGT SSSLQQKVKA STPLNSGALN 120
  121 ETVQNLKNME LDDPAPQPAK HSRVDRYEHP K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [641-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLEDNDSTIS SLESLKRENE ELREQLKVEH EENISMQKQL SELKGELNTL RSARKASPIG  60
   61 DRKPAFMRRA NTDFLELSTS PSFQRSVREF EPTRPKLYSS IDVNQRSPLA SAKTNGNFTF 120
  121 HAELPRSPFS SRANNINPDW TKAIDLAAKL KQKITEMKQT DQRHQGLIH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle