YRC Public Data Repository - Protein Structure Prediction

Protein:	baz-PA
Organism:	Drosophila melanogaster
Length:	1464 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for baz-PA.

Description	E-value	Query Range	Subject Range
gi\|7511813, gi\|4... - pir\|\|T13716 bazooka gene protein - fruit fly (Drosophila melanogaster), gi\|4127783\|emb\|CAA10224.1\| ...	675.0	[0..1]	[1464..1]

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Predicted Domain #1

Region A:
Residues: [1-71]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTVCFGDV RILVPCGSGE LLVRDLVKEA TRRYIKAAGK PDSWVTVTHL QTQSGILDPD  60
   61 DCVRDVADDR E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.045757
Match:	2ns5A
Description:	No description for 2ns5A was found.

Predicted Domain #2

Region A:
Residues: [72-302]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QILAHFDDPG PDPGVPQGGG DGASGSSSVG TGSPDIFRDP TNTEAPTCPR DLSTPHIEVT  60
   61 STTSGPMAGL GVGLMVRRSS DPNLLASLKA EGSNKRWSAA APHYAGGDSP ERLFLDKAGG 120
  121 QLSPQWEEDD DPSHQLKEQL LHQQQPHAAN GGSSSGNHQP FARSGRLSMQ FLGDGNGYKW 180
  181 MEAAEKLQNQ PPAQQTYQQG SHHAGHGQNG AYSSKSLPRE SKRKEPLGQA Y

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [303-416]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESIREKDGEM LLIINEYGSP LGLTALPDKE HGGGLLVQHV EPGSRAERGR LRRDDRILEI  60
   61 NGIKLIGLTE SQVQEQLRRA LESSELRVRV LRGDRNRRQQ RDSKVAEMVE VATV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.154902
Match:	1q7xA
Description:	Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	3.8598579619264	bayes_pls_golite062009
actin binding	2.68527541003929	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
protein binding	2.35875654816667	bayes_pls_golite062009
actin filament binding	1.28158096626765	bayes_pls_golite062009
receptor binding	1.19273986711251	bayes_pls_golite062009
transporter activity	1.14862709059264	bayes_pls_golite062009
transmembrane transporter activity	1.03502943752333	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
substrate-specific transporter activity	0.724101421194961	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
PDZ domain binding	0.71844819286977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.520243659117793	bayes_pls_golite062009
cell adhesion molecule binding	0.403457741099606	bayes_pls_golite062009
protein domain specific binding	0.30840185305841	bayes_pls_golite062009
ErbB-2 class receptor binding	0.261656236234201	bayes_pls_golite062009
active transmembrane transporter activity	0.221504678128513	bayes_pls_golite062009
molecular transducer activity	0.211809989510755	bayes_pls_golite062009
signal transducer activity	0.211809989510755	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [417-579]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPTRKPHAAP VGTSLQVANT RKLGRKIEIM LKKGPNGLGF SVTTRDNPAG GHCPIYIKNI  60
   61 LPRGAAIEDG RLKPGDRLLE VDGTPMTGKT QTDVVAILRG MPAGATVRIV VSRQQELAEQ 120
  121 ADQPAEKSAG VAVAPSVAPP AVPAAAAPAP PIPVQKSSSA RSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.30103
Match:	2fneA
Description:	The crystal structure of the 13th PDZ domain of MPDZ
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [580-630]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTHQQQSQLN ESQHFIDAGS ESAASNDSLP PSSNSWHSRE ELTLHIPVHD T

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [631-878]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKAGLGVSVK GKTCSNLNAS GSSASSGSNG LMKHDGDLGI FVKNVIHGGA ASRDGRLRMN  60
   61 DQLLSVNGVS LRGQNNAEAM ETLRRAMVNT PGKHPGTITL LVGRKILRSA SSSDILDHSN 120
  121 SHSHSHSNSS GGSNSNGSGN NNNSSSNASD NSGATVIYLS PEKREQRCNG GGGGGSAGNE 180
  181 MNRWSNPVLD RLTGGICSSN SAQPSSQQSH QQQPHPSQQQ QQQRRLPAAP VCSSAALRNE 240
  241 SYYMATND

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.69
Match:	1z87A
Description:	solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [879-950]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NWSPAQMHLM TAHGNTALLI EDDAEPMSPT LPARPHDGQH CNTSSANPSQ NLAVGNQGPP  60
   61 INTVPGTPST SS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [951-1273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFDATYSSQL SLETNSGVEH FSRDALGRRS ISEKHHAALD ARETGTYQRN KKLREERERE  60
   61 RRIQLTKSAV YGGSIESLTA RIASANAQFS GYKHAKTASS IEQRETQQQL AAAEAEARDQ 120
  121 LGDLGPSLGM KKSSSLESLQ TMVQELQMSD EPRGHQALRA PRGRGREDSL RAAVVSEPDA 180
  181 SKPRKTWLLE DGDHEGGFAS QRNGPFQSSL NDGKHGCKSS RAKKPSILRG IGHMFRFGKN 240
  241 RKDGVVPVDN YAVNISPPTS VVSTATSPQL QQQQQQQLQQ HQQQQQIPTA ALAALERNGK 300
  301 PPAYQPPPPL PAPNGVGSNG IHQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.0
Match:	1kjwA
Description:	Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1274-1464]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDIFNHRYQH YANYEDLHQQ HQQHQISRRH QHYHSQRSAR SQDVSMHSTS SGSQPGSLAQ  60
   61 PQAQSNGVRP MSSYYEYETV QQQRVGSIKH SHSSSATSSS SSPINVPHWK AAAMNGYSPA 120
  121 SLNSSARSRG PFVTQVTIRE QSSGGIPAHL LQQHQQQQLQ QQQPTYQTVQ KMSGPSQYGS 180
  181 AAGSQPHASK V

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: