YRC Public Data Repository - Protein Structure Prediction

Protein:	Npc2g-PA, FBpp02...
Organism:	Drosophila melanogaster
Length:	159 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Npc2g-PA, FBpp02....

Description	E-value	Query Range	Subject Range
gi\|220949268, gi... - gi\|220958328\|gb\|ACL91707.1\| CG11315-PA [synthetic construct], gi\|220949268\|gb\|ACL87177.1\| CG11315-PA... Npc2h-PA, FBpp02... - The gene Niemann-Pick type C-2h is referred to in FlyBase by the symbol Dmel\Npc2h (CG11315, FBgn003...	200.0	[0..1]	[159..1]
NPC2_BOVIN - Epididymal secretory protein E1 OS=Bos taurus GN=NPC2 PE=1 SV=1	179.0	[0..5]	[157..1]
gi\|74212648 - gi\|74212648\|dbj\|BAE31061.1\| unnamed protein product [Mus musculus]	168.0	[0..5]	[158..1]
gi\|27465565, gi\|... - gi\|34786047\|gb\|AAH58132.1\| Niemann-Pick disease, type C2 [Rattus norvegicus], gi\|27465565\|ref\|NP_775...	167.0	[0..5]	[157..1]
gi\|62896507 - gi\|62896507\|dbj\|BAD96194.1\| Niemann-Pick disease, type C2 precursor variant [Homo sapiens]	165.0	[0..18]	[158..14]
gi\|148234356, gi... - gi\|46249888\|gb\|AAH68868.1\| MGC82279 protein [Xenopus laevis], gi\|148234356\|ref\|NP_001084605.1\| hypot...	162.0	[0..5]	[158..3]

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Predicted Domain #1

Region A:
Residues: [1-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRPSSLQAV AIAIVLISSS ASAEVVNFEP CPDSVDTCTI QQVRVSPCPE ALNNAACNIR  60
   61 RKHNSEMSFD FTPNFDADTL VASLGWAKSE NVELPLLTLD SAACKYTPCP VRSGVKQTYT 120
  121 TLVPIEAKFP LSPYTIRWAL KDPVSQKRCC FTIDIKVVR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1nepA
Description:	Epididymal secretory protein E1 (Niemann-Pick C2 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.879052093832773	bayes_pls_golite062009
protein binding	0.80731472263402	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: