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View Structure Prediction Details

Protein: tmod-PC, tmod-PJ
Organism: Drosophila melanogaster
Length: 409 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tmod-PC, tmod-PJ.

Description E-value Query
Range
Subject
Range
gi|68388250 - gi|68388250|ref|XP_694145.1| PREDICTED: similar to PYRIN-containing APAF1-like protein 7 [Danio reri...
219.0 [0..28] [407..417]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADTAKDKDV IDQEDVEVEE QEETTTTTTT TKKTSQWHKT RTTKTSATTK TTTLTTPAKL  60
   61 YGKDLSEYDD VDVESLLAQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [80-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSPEEITILA KEVDPDDNFL PPDQRNSYEC TKEATGPLNR KQLIEHINKQ AIETPDQPEF  60
   61 EPFVQGKVRG KKWVPPPRDA RDIEAEEQIA IDMGEEYEHA LNDATQEEII DLAAILGFHS 120
  121 MMNQDQYHAS LLNKGQPVGL 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 7.744727
Match: PF03250.5
Description: No description for PF03250.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [220-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWDGITKSTQ QKLFPMDPPN NTDVEESIKR VKDDDSKLID LNLNNIKNIS DEKLEQLFAA  60
   61 LPQNEHLEVL SLTNVGLTDK TALLLAAAIE KSKTLRVLNV ETNFISPPVI VKLVQALLKC 120
  121 HTIEEFRASN QRSAVLGNKI EMEITDLVEK NSSLLRLGLH LEFNDARHRV AAHLQRNIDR 180
  181 IRVKRLNQRK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1io0A
Description: Tropomodulin C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule minus-end binding 7.70887263207962 bayes_pls_golite062009
cytoskeletal protein binding 5.04595324782806 bayes_pls_golite062009
actin binding 4.98528043340021 bayes_pls_golite062009
tropomyosin binding 2.80631683562112 bayes_pls_golite062009
binding 2.665591019824 bayes_pls_golite062009
protein binding 2.66138763326419 bayes_pls_golite062009
myosin binding 1.32546860780591 bayes_pls_golite062009
tubulin binding 1.00494145757097 bayes_pls_golite062009
microtubule binding 0.854246295331667 bayes_pls_golite062009
catalytic activity 0.143741655309638 bayes_pls_golite062009
Ras GTPase activator activity 0.0986232864289136 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle