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View Structure Prediction Details

Protein: CAP-D2-PA
Organism: Drosophila melanogaster
Length: 1380 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAP-D2-PA.

Description E-value Query
Range
Subject
Range
gi|37359800 - gi|37359800|dbj|BAC97878.1| mKIAA0159 protein [Mus musculus]
1209.0 [0..5] [1380..9]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEESHDFQFV LPLNASDLIN SSGDQYYVKE IFGAQEIPAK LQECKRKVHL GDPFYIFEHF  60
   61 DLYYSIIEAR GSDGASAQNL MRSFDLLYLT VEKLFQDLQP LLTASEPMSN QQRNSYLNLT 120
  121 KMTLFLQVST VKKINNSVQQ AMRDQQLNVQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [151-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRAKPSEGL EQFPNWEVKR GKFLVQLFNV LQCPLEKLWS PPVAEEDFIN LLCDPCYRTI  60
   61 ELLPLRMDNK HVFDTIFQIL GTSIKRFNQA MTFPVRILQI LRG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [254-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEHAAHSVAA GILLLHEEYG ISSVFSILIK SIVDALRMDS SDSSVSKHFS NFLAEFSNIA  60
   61 PSLIVPHLEK LAEDLLDCQS HTLRNCVLQI IGDTVVSELT SEDLSEELKE VRNEFLEHLM 120
  121 AHILDISAHV RSKVLSIWHH LKTQHAIPLN FLTRVLEEAI GRLEDKSSLV RRAAMHLIKS 180
  181 ALESNPYSSK LSIDELRAKH EHEVQAMEKL NEVLEEERKQ EEKLNDEFSS LAPELLPFIE 240
  241 ENLTEFPDMQ FDKEESDETL MERIIPLMRE KNYKDVIVLV RKVDFLAGNQ NMSSLLKHEE 300
  301 HCVYVLALLK TYHLLAAGFK QSSEEMLQQI KTVQFLKDSI DFAVLMTSAF PKLHEML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 1uklA
Description: Crystal structure of Importin-beta and SREBP-2 complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [611-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKTNTDVFE AVDLFTTGYM FGIHGTESGM QRMLQLVWSS DKEKRDAVSD AYKRVLFSTD  60
   61 QTGRAHAIKV VQNLSKFLSE IEYGHYTALE SLMTEWVLGG DIDAAVIQVL FERFTLKLEG 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [731-817]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTSNESRLSL QLLIMASQSK SSIVSANTAI IEDIAVGERV RRDPRIFTSC LQLLVNSIDA  60
   61 NNTAKYYKRQ NSDAEFVGKI TRLFLDF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [818-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FFHRSLYDFD ALAMSVFEYF YRMCQAPDVI AQQLVTALLK QFNESWLVKE AAAIVPSPDK  60
   61 ADTETVPDSQ PLEIPHSQTL TPTQTQADSQ SQMQGTLIPV YLVSRLIFCI GYMTIKEMIF 120
  121 LDMDIYNNMK YRDELTALEE RKNRNQQAGS SHNAARLTLN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [978-1380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAMEVRKRL SGVAAEPQQE PDDDLVGATA EDNIAEEIHG ICEDMLLYNP DALLSKLAPF  60
   61 IIEICKRPGE FGDPTLQQAA TLALARLMTV SSRFCESNMS FLMNILNLTK NIRIKCNTVV 120
  121 GLSDLTFRFP NIIEPWTGHF YAQLHESNTE LRLTAVKMLS HLILNEMIRV KGQIADMALC 180
  181 IVDGNEEIRN ITKQFFKEIA NKSNILYNVL PDIISRLGDI NLNLDEDKYR IIMSYILGLI 240
  241 QKDRQIETLV EKLCLRFPVT RVERQWRDIA YCLGLLTYNE RAVKKLMDNM QHYRDKVQVD 300
  301 EVYQSFKLII SNTNKLAKPE LKAVVTEFEN RLNECLQVNP DTAAQGDQES TPEGQGNRTR 360
  361 AAPRTKKGGR KPAANRNNTV RGRGRRARRD STSEESFSSS SSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.045757
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.91891696274037 bayes_pls_golite062009
protein binding 1.94427330399472 bayes_pls_golite062009
cytoskeletal protein binding 1.61037669901273 bayes_pls_golite062009
actin binding 0.891762677781115 bayes_pls_golite062009
nucleic acid binding 0.169755106399802 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle