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View Structure Prediction Details

Protein: CG11874-PA
Organism: Drosophila melanogaster
Length: 685 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG11874-PA.

Description E-value Query
Range
Subject
Range
gi|109109679 - gi|109109679|ref|XP_001091256.1| PREDICTED: alpha 1,2-mannosidase isoform 2 [Macaca mulatta]
748.0 [0..2] [684..47]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDGGHITLT LPPGSAATTD ERGRKSLRRA WNQLPRCQRN LIILGITGFC VTVLLCLSGD  60
   61 QLLAASLKDV DTKAEVAAYQ MPLPNPHHHP GVDKDVPKDT AAVPVPADKR APRVEAVSDK 120
  121 FNELVAYGEA NSAENVARLP ETVAAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLPQASAMAV ALPPPDSNKE QDIGGIDILN NVEEPVAQDP AEPLSEGEQL EQAIKNPLTL  60
   61 GGVSFKEHLK KIKPILAKGQ HFHGATNERQ SAVVAAFKHS WAGYKKYAWG HDNLKPISQY 120
  121 SHEWFGLGLT IVDSLDTMYI MGLDDEFKEG RDWVEQSLRF DTKRDVNLFE VTIRVLGGLL 180
  181 SAYHLSGDTM FLAKAAELGN RLLPAFQSPS NIPYSDVNLG DLSAHSPKWS PDSSTSEVTT 240
  241 IQLEFRDLSR STNISIYEQV AHKVNEKVHD LEKNHGLVPI FINANTGTFR NYATISLGAR 300
  301 GDSYYEYLLK QWIQTGRKDN DNLILDYMQA VDGVLTQLMR RTPREHWVYI GELINGKDFK 360
  361 PKMDHLTCYL PGTLILGHQN GMPDSHLILA RDLLDTCYQT YMMNPTHLAA EISYFALTEK 420
  421 DDQDIYVKPN DAHNLLRPEF VESLYYFYSI TGNRTYQDMG WKIFQAFETH AKVNAGYTSM 480
  481 GNVKNTQSTR LRDLMESFWM SETLKYFYLL FSDDRKEIDL EQWVFNSEGH PLPVYPLKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1x9dA
Description: Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyl-oligosaccharide mannosidase activity 7.089685350864 bayes_pls_golite062009
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 6.95179264736435 bayes_pls_golite062009
mannosidase activity 5.20286438265852 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 4.31319275372149 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.65589746311782 bayes_pls_golite062009
hydrolase activity 2.67964748309919 bayes_pls_golite062009
binding 1.49199031708525 bayes_pls_golite062009
catalytic activity 1.31873306707813 bayes_pls_golite062009
cation binding 0.362242764130218 bayes_pls_golite062009
metal ion binding 0.362242764130218 bayes_pls_golite062009
protein binding 0.36081692928767 bayes_pls_golite062009
ion binding 0.355220167272296 bayes_pls_golite062009
calcium ion binding 0.121126738064555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle