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View Structure Prediction Details

Protein: FBpp0302815, dnk-PA
Organism: Drosophila melanogaster
Length: 250 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0302815, dnk-PA.

Description E-value Query
Range
Subject
Range
gi|54638612, gi|... - gi|54638612|gb|EAL28014.1| GA18891 [Drosophila pseudoobscura pseudoobscura], gi|125775239|ref|XP_001...
gi|54638612|gb|E... - GA18891-PA [Drosophila pseudoobscura], GA18891 [Drosophila pseudoobscura pseudoobscura]
176.0 [0..1] [250..1]
gi|88191978, gi|... - gi|88191978|pdb|2A30|D Chain D, Crystal Structure Of Human Deoxycytidine Kinase In Complex With Deox...
176.0 [0..1] [232..4]
gi|109074540 - gi|109074540|ref|XP_001093411.1| PREDICTED: deoxycytidine kinase [Macaca mulatta]
166.0 [0..1] [244..1]
gi|54696740, gi|... - gi|61367811|gb|AAX43050.1| deoxycytidine kinase [synthetic construct], gi|61367804|gb|AAX43049.1| de...
166.0 [0..1] [232..1]
gi|88912775, gi|... - gi|88931496|ref|ZP_01137190.1| Thymidylate kinase [Acidothermus cellulolyticus 11B], gi|88912775|gb|...
165.0 [0..8] [246..453]
gi|38492611, gi|... - gi|38492611|pdb|1OE0|D Chain D, Crystal Structure Of Drosophila Deoxyribonucleoside Kinase In Comple...
165.0 [0..1] [230..1]

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Predicted Domain #1
Region A:
Residues: [1-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAASCARK GTKYAEGTQP FTVLIEGNIG SGKTTYLNHF EKYKNDICLL TEPVEKWRNV  60
   61 NGVNLLELMY KDPKKWAMPF QSYVTLTMLQ SHTAPTNKKL KIMERSIFSA RYCFVENMRR 120
  121 NGSLEQGMYN TLEEWYKFIE ESIHVQADLI IYLRTSPEVA YERIRQRARS EESCVPLKYL 180
  181 QELHELHEDW LIHQRRPQSC KVLVLDADLN LENIGTEYQR SESSIFDAIS SNQQPSPVLV 240
  241 SPSKRQRVAR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.0
Match: 1ot3A
Description: Deoxyribonucleoside kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.66392587433723 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
binding 1.46714820387895 bayes_pls_golite062009
adenylate kinase activity 1.27088333982087 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.00388614309685 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.872487338145151 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.854269100162193 bayes_pls_golite062009
CTP synthase activity 0.554689818807922 bayes_pls_golite062009
nucleic acid binding 0.503971340374059 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.450562042301179 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
hydrolase activity 0.420858111948277 bayes_pls_golite062009
protein binding 0.232442551591362 bayes_pls_golite062009
transferase activity 0.175269600441384 bayes_pls_golite062009
DNA binding 0.111331583742205 bayes_pls_golite062009
protein kinase activity 0.0646123847220056 bayes_pls_golite062009

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Created and Maintained by: Michael Riffle