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View Structure Prediction Details

Protein: by-PC, by-PA, by-PD
Organism: Drosophila melanogaster
Length: 720 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for by-PC, by-PA, by-PD.

Description E-value Query
Range
Subject
Range
gi|63803 - gi|63803|emb|CAA46992.1| tensin [Gallus gallus]
338.0 [0..457] [716..3]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTPYEESAA AADHKYQYQY TAANNNNNYY KNYNVNGNGQ ANGNGNLSGI GNGNGIGNGN  60
   61 GYGIPYHARE NSLPFSYGIA KTSTPLRKTP TPTRVDSFLD FDFGPTNT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVNSNSSSNN GGTGDMIKPP TRLTSPLLVR KTLGNAVSPT SSTNTNTIAN TYHYTSSSAT  60
   61 PTPVRDNFEQ LLRERREKVY NEYRNL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [195-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRESSGERAR VAPAPPQRQY YPSDGYGIGL KNDSNGTLYR KSPSSNGKST KYNYDFEFNL  60
   61 NLDDVRPEPT PYTTRNIHFE DLRLDQDVPD GVVNRRTMER NYHTINSLET TH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [307-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRQQLEPLEQ LGAVYGQNHM EETLTRTRRD LSASTSTSKS TSPLPAIGVP AIAPASPIYA  60
   61 TSTKRVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [374-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPNTNGQQQM TPSPTSRPET PAFPVTPRTP FGASSSSSAS LAPTTQLPPE SIYQTGPRRG  60
   61 VPPALQPLEV SAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.221849
Match: 1g83A
Description: Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [447-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVQFARSSSQ FWYKPNLTRE DAIALLASAQ PGTFLVRDST TYKDSYGLVV RVSQPPPGSQ  60
   61 ELVRHFLIEP TKGGVHLKGC DDEPVFTSLS ALVFEHSISQ LALPCLLRLP DRDIVPPVRA 120
  121 TTPAQQHLLA HGAATNVLWL YSCDTESLTG NEAIRKAIRQ MYGQQPLPQP TEVHFKVSSQ 180
  181 GITLTDNTRK KFFRKHYKAD VISHCAIDPE NRMWTSEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 1m61A
Description: Tyrosine-protein kinase zap-70
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.28887512041698 bayes_pls_golite062009
signal transducer activity 2.07133863841547 bayes_pls_golite062009
molecular transducer activity 2.07133863841547 bayes_pls_golite062009
protein binding 2.04603930248857 bayes_pls_golite062009
molecular adaptor activity 0.93584922485564 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.72842829338771 bayes_pls_golite062009
receptor binding 0.49361386378291 bayes_pls_golite062009
protein binding, bridging 0.192710997278041 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [665-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESDKKTIFAF VARRSHSSTD NQCHVFCDLS VSQPAAAIVS FANRTLPTEK LRNYVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.045757
Match: 2gjyA
Description: No description for 2gjyA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle