YRC Public Data Repository - Protein Structure Prediction

Protein:	CG4365-PB
Organism:	Drosophila melanogaster
Length:	271 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG4365-PB.

Description	E-value	Query Range	Subject Range
CG4365-PC - This gene is referred to in FlyBase by the symbol Dmel\CG4365 (CG4365, FBgn0037024). It is a protein...	256.0	[0..1]	[271..78]
gi\|125977966, gi... - gi\|54641767\|gb\|EAL30517.1\| GA18136-PA [Drosophila pseudoobscura], gi\|125977966\|ref\|XP_001353016.1\| G...	254.0	[0..1]	[271..72]
gi\|25406895, gi\|... - gi\|8810475\|gb\|AAF80136.1\|AC024174_18 Contains similarity to glyoxalase II isozyme from Arabidopsis t...	229.0	[0..11]	[271..255]
gi\|91088179 - gi\|91088179\|ref\|XP_972438.1\| PREDICTED: similar to CG4365 CG4365-PA [Tribolium castaneum]	228.0	[0..2]	[270..36]
gi\|66911967 - gi\|66911967\|gb\|AAH97301.1\| Hagh protein [Rattus norvegicus]	227.0	[0..7]	[270..39]
gi\|67856075, gi\|... - gi\|67922175\|ref\|ZP_00515690.1\| Hydroxyacylglutathione hydrolase [Crocosphaera watsonii WH 8501], gi\|...	227.0	[0..13]	[269..1]
gi\|86605820 - gi\|86605820\|ref\|YP_474583.1\| glyoxalase II family protein [Cyanobacteria bacterium Yellowstone A-Pri... GLO2_SYNJA - Hydroxyacylglutathione hydrolase OS=Synechococcus sp. (strain JA-3-3Ab) GN=gloB PE=3 SV=1	225.0	[0..13]	[269..1]

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Predicted Domain #1

Region A:
Residues: [1-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSTLEDVQL EGMEIKILPA LQDNYMYLIV DTKTREAAVV DPVEPELVIK TVQEQQLTLS  60
   61 KVLTTHHHWD HAGGNEKLLK LWEKELDVYG GDDRIGALNK KVQQDDTFTI GGLHVKCLST 120
  121 PCHTTGHICY HITAQQGSGE GAVFTGDTLF QGGCGRFFEG TPEEMYEALC TKLSALPDAT 180
  181 KVFCGHEYTL QNMSFARHVE PDNEVIQQRI EWAKHRRASQ DPTVPSTIGE EKSWNPFMRV 240
  241 HEATVQKHAG GATDPVVTMG KLRKEKDTFK A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.522879
Match:	1qh3A
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacylglutathione hydrolase activity	3.53012507604564	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
binding	0.900972948435178	bayes_pls_golite062009
thiolester hydrolase activity	0.802604883362264	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: