YRC Public Data Repository - Protein Structure Prediction

Protein:	CG11796-PB
Organism:	Drosophila melanogaster
Length:	294 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG11796-PB.

Description	E-value	Query Range	Subject Range
HPPD_ZYMTR - 4-hydroxyphenylpyruvate dioxygenase OS=Zymoseptoria tritici GN=HPPD PE=3 SV=1 HPPD_MYCGR - 4-hydroxyphenylpyruvate dioxygenase OS=Mycosphaerella graminicola GN=HPPD PE=3 SV=1	343.0	[0..2]	[294..126]
HPPD_NEUCR - 4-hydroxyphenylpyruvate dioxygenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.7... HPPD_NEUCR - 4-hydroxyphenylpyruvate dioxygenase OS=Neurospora crassa GN=B23G1.170 PE=3 SV=1	341.0	[0..2]	[294..117]
gi\|157105932, gi... - gi\|157105932\|ref\|XP_001649088.1\| 4-hydroxyphenylpyruvate dioxygenase [Aedes aegypti], gi\|108868917\|g...	341.0	[0..1]	[294..87]
CG11796-PA - This gene is referred to in FlyBase by the symbol Dmel\CG11796 (CG11796, FBgn0036992). It is a prote... gi\|220959738, gi... - gi\|220959738\|gb\|ACL92412.1\| CG11796-PA [synthetic construct], gi\|220951448\|gb\|ACL88267.1\| CG11796-PA...	341.0	[0..1]	[294..87]
gi\|114647465 - gi\|114647465\|ref\|XP_528667.2\| PREDICTED: 4-hydroxyphenylpyruvate dioxygenase isoform 3 [Pan troglody...	341.0	[0..1]	[294..87]
gi\|157775775 - gi\|157775775\|ref\|XP_001665953.1\| hypothetical protein CBG18361 [Caenorhabditis briggsae AF16] HPPD_CAEBR - 4-hydroxyphenylpyruvate dioxygenase OS=Caenorhabditis briggsae GN=hpd-1 PE=3 SV=1	340.0	[0..1]	[294..86]
gi\|3860238 - gi\|3860238\|gb\|AAC73008.1\| 4-hydroxyphenylpyruvate-dioxygenase [Homo sapiens]	340.0	[0..1]	[294..87]
gi\|55236821, gi\|... - gi\|58390825\|ref\|XP_318007.2\| ENSANGP00000010800 [Anopheles gambiae str. PEST], gi\|55236821\|gb\|EAA132...	340.0	[0..1]	[294..86]
gi\|109099057 - gi\|109099057\|ref\|XP_001096175.1\| PREDICTED: 4-hydroxyphenylpyruvate dioxygenase isoform 2 [Macaca mu...	339.0	[0..1]	[294..87]

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Predicted Domain #1

Region A:
Residues: [1-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHGDGVKDV AFEVEDLNAI FTLAVSRGAE VVRDIWEESD DQGFVRFATI KTYGDTTHTF  60
   61 VERNGYAGDF LPGFQRSPKD VLLNGLPSTK LNFIDHVVGN QPDLQMESVA SWYERILQFH 120
  121 RFWSVDDSQI HTEYSALRSI VMANYEETVK MPINEPANGK KKSQIQEYVE YYGGGGVQHI 180
  181 ALNTDDIIEA VSNLKARGTE FLTIPSSYYE ILQEQLSHSR TKIKEDMEVL KKLNILIDFD 240
  241 ENGYLLQIFT KNCQDRPTLF LEVIQRYNHN GFGAGNFKSL FTAIEIEQAK RGNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.221849
Match:	1sqiA
Description:	Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.58822083914233	bayes_pls_golite062009
carbon-sulfur lyase activity	0.31693173994125	bayes_pls_golite062009
lyase activity	0.17363224963028	bayes_pls_golite062009
4-hydroxyphenylpyruvate dioxygenase activity	0.0158056897201302	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: