YRC Public Data Repository - Protein Structure Prediction

Protein:	Ilp1-PA
Organism:	Drosophila melanogaster
Length:	154 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ilp1-PA.

Description	E-value	Query Range	Subject Range
gi\|37220722 - gi\|37220722\|gb\|AAQ89694.1\| insulin-like peptide 3 precursor [Anopheles gambiae] gi\|116128050, gi... - gi\|118785366\|ref\|XP_001237579.1\| AGAP010602-PA [Anopheles gambiae str. PEST], gi\|116128050\|gb\|EAU767...	112.0	[0..3]	[151..2]
AGAP010604-PA - Insulin-like peptide 3 precursor\|protein_coding\|3L:7128805:7129369:-1\|gene:AGAP010604 gi\|118785370, gi... - gi\|118785370\|ref\|XP_314567.3\| AGAP010604-PA [Anopheles gambiae str. PEST], gi\|116128052\|gb\|EAA09943....	111.0	[0..3]	[151..2]
gi\|220944078, gi... - gi\|220954052\|gb\|ACL89569.1\| Ilp2-PA [synthetic construct], gi\|220944078\|gb\|ACL84582.1\| Ilp2-PA [synt... Ilp2-PA - The gene Insulin-like peptide 2 is referred to in FlyBase by the symbol Dmel\Ilp2 (CG8167, FBgn00360...	102.0	[0..23]	[151..5]
INS_ORENI - Insulin OS=Oreochromis niloticus GN=ins PE=1 SV=2	102.0	[0..13]	[152..4]
INS1_RAT - Insulin-1 OS=Rattus norvegicus GN=Ins1 PE=1 SV=1	102.0	[0..19]	[152..1]
INS_LOPPI - (P01341) Insulin precursor INS_LOPAM - Insulin OS=Lophius americanus GN=ins PE=3 SV=1	101.0	[0..13]	[152..4]
INS_VERMO - Insulin OS=Verasper moseri GN=ins PE=3 SV=1	100.0	[0..20]	[152..3]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSQHNGAAV HGLRLQSLLI AAMLTAAMAM VTPTGSGHQL LPPGNHKLCG PALSDAMDVV  60
   61 CPHGFNTLPR KRESLLGNSD DDEDTEQEVQ DDSSMWQTLD GAGYSFSPLL TNLYGSEVLI 120
  121 KMRRHRRHLT GGVYDECCVK TCSYLELAIY CLPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.09691
Match:	3lriA
Description:	Insulin-like growth factor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor binding	4.96234302646827	bayes_pls_golite062009
insulin-like growth factor receptor binding	4.48857896892351	bayes_pls_golite062009
growth factor activity	4.19304935106952	bayes_pls_golite062009
insulin receptor binding	3.85109459565499	bayes_pls_golite062009
binding	2.07081269731637	bayes_pls_golite062009
insulin-like growth factor binding	1.91342474664514	bayes_pls_golite062009
growth factor binding	1.84573028463276	bayes_pls_golite062009
protein binding	1.63714982602479	bayes_pls_golite062009
hormone activity	1.5588633384762	bayes_pls_golite062009
protein complex binding	1.3998769992239	bayes_pls_golite062009
protease binding	0.110306213143451	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: