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View Structure Prediction Details

Protein: Cht4-PA
Organism: Drosophila melanogaster
Length: 462 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cht4-PA.

Description E-value Query
Range
Subject
Range
Cht8-PA - The gene Cht8 is referred to in FlyBase by the symbol Dmel\Cht8 (CG9357, FBgn0034580). It is a prote...
354.0 [0..3] [461..8]

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Predicted Domain #1
Region A:
Residues: [1-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLVSIWALA ALCLCLGQVA SSEKLLNCYW GTWANYRPGD GKFTPSDIDP SLCTHISYTF  60
   61 FGISDAGEFK SLDTWLDMDD GLGFISQTIA LKQRNPNLKI LAVVGGWNEG STKYSAMAAD 120
  121 PAKRATFVST SLAFIQQYSF DGLDLDWEYP GQRGGSEADR ENFVTLLREI KETYDQYGLE 180
  181 LGIAVGASEK SASISYDIPA ISQHLTFINV MTYDFHMALD GYLGLNAPLP EVAESIDYWL 240
  241 SHGAPAEKLI LGIGFYGHSY QMSDSSQNWP GAACIGPGTA GVYTRENGFL GYHEICLNNW 300
  301 QTVFDQENGA PYAFQGDQWI GYDNPESIQL KMQLVESRNL GGAMMWSIET DDFRGLCGES 360
  361 YPLLKTMNRA LGREVSGGSG GGGGGGGEGS VTPAPTAAPT SSPTPAPTPG GGSGGNECAQ 420
  421 DGFFVLESDC NKFYQCVGGV RYDFQCGAGL CFNTITLNCD WP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.39794
Match: 1wawA
Description: Specificity and affnity of natural product cyclopentapeptide inhibitor Argadin against human chitinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
chitinase activity 6.40555694403866 bayes_pls_golite062009
imaginal disc growth factor activity 3.9608908661313 bayes_pls_golite062009
growth factor activity 2.18932950777991 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 1.91170236789651 bayes_pls_golite062009
receptor binding 1.89435893935497 bayes_pls_golite062009
amylase activity 1.38959979746158 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 1.34796838721403 bayes_pls_golite062009
chitin binding 1.29046765706168 bayes_pls_golite062009
binding 1.1885466730171 bayes_pls_golite062009
carbohydrate binding 0.80333288291596 bayes_pls_golite062009
glucosidase activity 0.766503513427695 bayes_pls_golite062009
protein binding 0.690517649847952 bayes_pls_golite062009
catalytic activity 0.534516847146079 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.266938437560648 bayes_pls_golite062009
hexosaminidase activity 0.21148675734804 bayes_pls_golite062009
hydrolase activity 0.178746202646272 bayes_pls_golite062009
pattern binding 0.113396113487931 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle