YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF12_RAT
Organism:	Rattus norvegicus
Length:	243 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF12_RAT.

Description	E-value	Query Range	Subject Range
gi\|224060562 - gi\|224060562\|ref\|XP_002190247.1\| PREDICTED: fibroblast growth factor 12 isoform 2 [Taeniopygia gutta... gi\|45382435, gi\|... - gi\|45382435\|ref\|NP_990219.1\| fibroblast growth factor 12 [Gallus gallus], gi\|4512020\|gb\|AAD21575.1\| ...	8.0E-80	[1..243]	[1..243]
gi\|109053910 - gi\|109053910\|ref\|XP_001094765.1\| PREDICTED: similar to Fibroblast growth factor 12 (FGF-12) (Fibrobl...	2.0E-79	[1..243]	[1..243]
gi\|18539229, gi\|... - gi\|18677741\|ref\|NP_570827.1\| fibroblast growth factor 12 [Rattus norvegicus], gi\|18539229\|dbj\|BAB845...	2.0E-79	[1..243]	[1..243]
gi\|2444479 - gi\|2444479\|gb\|AAB71607.1\| fibroblast growth factor-related protein FGF-12A [Mus musculus]	1.0E-78	[1..243]	[1..243]
gi\|68434896, gi\|... - gi\|68434896\|ref\|XP_694734.1\| PREDICTED: similar to Fibroblast growth factor-12 (FGF-12) (Fibroblast ...	8.0E-74	[3..243]	[2..241]
gi\|114650543 - gi\|114650543\|ref\|XP_001150157.1\| PREDICTED: fibroblast growth factor 14 isoform 1 [Pan troglodytes] gi\|109121204 - gi\|109121204\|ref\|XP_001093573.1\| PREDICTED: fibroblast growth factor 14 isoform 2 [Macaca mulatta] FGF14 - fibroblast growth factor 14	3.0E-73	[1..243]	[1..246]
gi\|60811740, gi\|... - gi\|60825649\|gb\|AAX36728.1\| fibroblast growth factor 13 [synthetic construct], gi\|60811740\|gb\|AAX3618...	2.0E-71	[1..243]	[1..244]

Back

Predicted Domain #1

Region A:
Residues: [1-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR  60
   61 PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 120
  121 VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 180
  181 GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 240
  241 DST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.69897
Match:	1q1uA
Description:	Crystal structure of human FHF1b (FGF12b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor binding	4.30358117760805	bayes_pls_golite062009
growth factor activity	3.97089267530575	bayes_pls_golite062009
cytokine activity	3.76931834545338	bayes_pls_golite062009
binding	2.90110516688922	bayes_pls_golite062009
protein binding	1.94397222237906	bayes_pls_golite062009
fibroblast growth factor receptor binding	1.9437092554389	bayes_pls_golite062009
pattern binding	0.839280621598109	bayes_pls_golite062009
interleukin-1 receptor binding	0.8084616632765	bayes_pls_golite062009
glycosaminoglycan binding	0.69866345905635	bayes_pls_golite062009
heparin binding	0.290941670257021	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: