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View Structure Prediction Details

Protein: gi|123993801, gi...
Organism: synthetic construct
Length: 280 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123993801, gi....

Description E-value Query
Range
Subject
Range
gi|74002275 - gi|74002275|ref|XP_535669.2| PREDICTED: similar to Dual adapter for phosphotyrosine and 3-phosphotyr...
2.0E-45 [1..280] [1..280]
gi|5733602 - gi|5733602|gb|AAD49698.1|AF163255_1 adaptor protein DAPP1 [Mus musculus]
5.0E-45 [1..280] [1..280]
gi|115304852, gi... - gi|116004005|ref|NP_001070359.1| dual adaptor of phosphotyrosine and 3-phosphoinositides [Bos taurus...
4.0E-44 [1..279] [1..279]
gi|109075106 - gi|109075106|ref|XP_001107831.1| PREDICTED: dual adaptor of phosphotyrosine and 3-phosphoinositides ...
3.0E-42 [1..279] [1..279]
gi|109465629, gi... - ref|XP_342349.1| similar to B lymphocyte adapter protein BAM32 [Rattus norvegicus], gi|157819323|ref...
3.0E-41 [1..280] [1..279]
gi|6503078, gi|7... - gi|7657007|ref|NP_055210.1| dual adaptor of phosphotyrosine and 3-phosphoinositides [Homo sapiens], ...
8.0E-39 [1..255] [1..255]
gi|114595354 - gi|114595354|ref|XP_001167588.1| PREDICTED: dual adaptor of phosphotyrosine and 3-phosphoinositides ...
2.0E-38 [1..255] [1..255]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL  60
   61 RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG 120
  121 TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2b3oA
Description: Crystal structure of human tyrosine phosphatase SHP-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [159-280]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTAPSLGTKE GYLTKQGGLV KTWKTRWFTL HRNELKYFKD QMSPEPIRIL DLTECSAVQF  60
   61 DYSQERVNCF CLVFPFRTFY LCAKTGVEAD EWIKILRWKL SQIRKQLNQG EGTIRSRSFI 120
  121 FK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1faoA
Description: Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.38944296108213 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.33259876797866 bayes_pls_golite062009
protein binding 1.8661085728568 bayes_pls_golite062009
phosphatase activity 1.77726075593314 bayes_pls_golite062009
phosphoric ester hydrolase activity 1.76530166849621 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.50761655608693 bayes_pls_golite062009
hydrolase activity 1.35918203825049 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle