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View Structure Prediction Details

Protein: COL6A2
Organism: Homo sapiens
Length: 1019 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COL6A2.

Description E-value Query
Range
Subject
Range
gi|41350923 - gi|41350923|gb|AAH65509.1| Collagen, type VI, alpha 2 [Homo sapiens]
gi|190691377, gi... - gi|190691377|gb|ACE87463.1| collagen, type VI, alpha 2 protein [synthetic construct], gi|190690005|g...
0.0 [1..1019] [1..1019]
gi|109065029, gi... - gi|109065031|ref|XP_001099130.1| PREDICTED: similar to alpha 2 type VI collagen isoform 2C2 precurso...
0.0 [1..1019] [1..1019]
CO6A2_CHICK - Collagen alpha-2(VI) chain OS=Gallus gallus GN=COL6A2 PE=2 SV=1
0.0 [1..1019] [8..1022]
gi|109509328, gi... - gi|149043684|gb|EDL97135.1| procollagen, type VI, alpha 2, isoform CRA_a [Rattus norvegicus], gi|109...
0.0 [1..1019] [7..1027]
CO6A2_MOUSE - Collagen alpha-2(VI) chain OS=Mus musculus GN=Col6a2 PE=1 SV=3
0.0 [1..1019] [6..1034]
gi|114684887 - gi|114684887|ref|XP_531504.2| PREDICTED: alpha 2 type VI collagen [Pan troglodytes]
0.0 [1..1019] [158..1159]

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Predicted Domain #1
Region A:
Residues: [1-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQGTCSVLL LWGILGAIQA QQQEVISPDT TERNNNCPEK TDCPIHVYFV LDTSESVTMQ  60
   61 SPTDILLFHM KQFVPQFISQ LQNEFYLDQV ALSWRYGGLH FSDQVEVFSP PGSDRASFIK 120
  121 NLQGISSFRR GTFTDCALAN MTEQIRQDRS KGTVHFAVVI TDGHVTGSPC GGIKLQAERA 180
  181 REEGIRLFAV APNQNLKEQG LRDIASTPHE LYRNDYATML PDSTEIDQDT INRIIKVMKH 240
  241 EAYGECYKVS CLEIPGPSGP KGYRGQKGAK GNMGEPGEPG QKGRQGDPGI EGPIGFPGPK 300
  301 GVPGFKGEKG EFGADGRKGA PGLAGKNGTD GQKGKLGRIG PPGCKGDPGN RGPDGYPGEA 360
  361 GSPGERGDQG GKGDPGRPGR RGPPGEIGAK GSKGYQGNSG APGSPGVKGA KGGPGPRGPK 420
  421 GEPGRRGDPG TKGSPGSDGP KGEKGDPGPE GPRGLAGEVG NKGAKGDRGL PGPRGPQGAL 480
  481 GEPGKQGSRG DPGDAGPRGD SGQPGPKGDP GRPGFSYPGP RGAPGEKGEP GPRGPEGGRG 540
  541 DFGLKGEPGR KGEKGEPADP GPPGEPGPRG PRGVPGPEGE PGPPGDPGLT ECDVMTYVRE 600
  601 TCGCCDCEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.39794
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #2
Region A:
Residues: [610-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCGALDVVFV IDSSESIGYT NFTLEKNFVI NVVNRLGAIA KDPKSETGTR VGVVQYSHEG  60
   61 TFEAIQLDDE RIDSLSSFKE AVKNLEWIAG GTWTPSALKF AYDRLIKESR RQKTRVFAVV 120
  121 ITDGRHDPRD DDLNLRALCD RDVTVTAIGI GDMFHEKHES ENLYSIACDK PQQVRNMTLF 180
  181 SDLVAEKFID DMEDVLCPDP QIVCPDLPCQ T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1u0oC
Description: The mouse von Willebrand Factor A1-botrocetin complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [821-1019]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELSVAQCTQR PVDIVFLLDG SERLGEQNFH KARRFVEQVA RRLTLARRDD DPLNARVALL  60
   61 QFGGPGEQQV AFPLSHNLTA IHEALETTQY LNSFSHVGAG VVHAINAIVR SPRGGARRHA 120
  121 ELSFVFLTDG VTGNDSLHES AHSMRKQNVV PTVLALGSDV DMDVLTTLSL GDRAAVFHEK 180
  181 DYDSLAQPGF FDRFIRWIC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.39794
Match: 1jlmA
Description: I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
extracellular matrix structural constituent 5.35512843823459 bayes_pls_golite062009
collagen binding 3.02661336895748 bayes_pls_golite062009
integrin binding 2.88072615891929 bayes_pls_golite062009
cell adhesion molecule binding 2.82246206393797 bayes_pls_golite062009
glycosaminoglycan binding 1.99205622721239 bayes_pls_golite062009
binding 1.97047580255231 bayes_pls_golite062009
protein binding 1.74050731797598 bayes_pls_golite062009
glycoprotein binding 1.69506686059649 bayes_pls_golite062009
receptor binding 1.45722320869741 bayes_pls_golite062009
protein complex binding 1.225591377849 bayes_pls_golite062009
extracellular matrix structural constituent conferring tensile strength 0.711915074769859 bayes_pls_golite062009
carbohydrate binding 0.70256601942196 bayes_pls_golite062009
pattern binding 0.376098362886939 bayes_pls_golite062009
polysaccharide binding 0.292637914469249 bayes_pls_golite062009
heparan sulfate proteoglycan binding 0.148637005031519 bayes_pls_golite062009
heparin binding 0.0972358234583903 bayes_pls_golite062009
protease binding 0.0133712327786606 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle