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View Structure Prediction Details

Protein: gi|220325, gi|74...
Organism: Mus musculus
Length: 215 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|220325, gi|74....

Description E-value Query
Range
Subject
Range
FGF8_CHICK - Fibroblast growth factor 8 OS=Gallus gallus GN=FGF8 PE=2 SV=1
3.0E-66 [1..214] [1..214]
gi|213624952, gi... - gi|27462802|gb|AAO15593.1|AF461177_1 fibroblast growth factor-8b [Xenopus laevis], gi|213626476|gb|A...
5.0E-66 [1..210] [1..210]
gi|51949976, gi|... - gi|56118518|ref|NP_001008163.1| fibroblast growth factor 8 (androgen-induced) [Xenopus (Silurana) tr...
6.0E-66 [1..210] [1..210]
gi|16305069 - gi|16305069|gb|AAL16958.1|AF360985_1 fibroblast growth factor 8 [Ambystoma mexicanum]
3.0E-64 [2..205] [5..208]
gi|28913543 - gi|28913543|gb|AAH48734.1| Fgf8 protein [Mus musculus]
1.0E-62 [20..215] [49..244]
gi|1399443, gi|2... - gi|3165383|dbj|BAA28605.1| FGF8f [Homo sapiens], gi|21489896|gb|AAM55238.1|AF520763_1 fibroblast gro...
1.0E-62 [20..215] [49..244]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPRSALSC LLLHLLVLCL QAQVTVQSSP NFTQHVREQS LVTDQLSRRL IRTYQLYSRT  60
   61 SGKHVQVLAN KRINAMAEDG DPFAKLIVET DTFGSRVRVR GAETGLYICM NKKGKLIAKS 120
  121 NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPR 180
  181 GHHTTEQSLR FEFLNYPPFT RSLRGSQRTW APEPR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.30103
Match: 2fdbM
Description: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 5.6790632853895 bayes_pls_golite062009
fibroblast growth factor receptor binding 5.32138222782692 bayes_pls_golite062009
receptor binding 4.8109037277027 bayes_pls_golite062009
cytokine activity 3.23273280319483 bayes_pls_golite062009
protein binding 2.99442649109752 bayes_pls_golite062009
binding 2.26121569090272 bayes_pls_golite062009
heparin binding 2.1616134585534 bayes_pls_golite062009
glycosaminoglycan binding 2.0664969520492 bayes_pls_golite062009
polysaccharide binding 1.81686028727894 bayes_pls_golite062009
molecular transducer activity 1.16870777190189 bayes_pls_golite062009
signal transducer activity 1.16870777190189 bayes_pls_golite062009
transporter activity 0.901374747438933 bayes_pls_golite062009
interleukin-1 receptor binding 0.8084616632765 bayes_pls_golite062009
transmembrane transporter activity 0.718170110067115 bayes_pls_golite062009
substrate-specific transporter activity 0.507427648555795 bayes_pls_golite062009
pattern binding 0.323275442862789 bayes_pls_golite062009
nerve growth factor receptor binding 0.308245352535379 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.280573521182099 bayes_pls_golite062009
receptor signaling protein activity 0.146644241088165 bayes_pls_golite062009
ion transmembrane transporter activity 0.0138670393997913 bayes_pls_golite062009

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