YRC Public Data Repository - Protein Structure Prediction

Protein:	GLO2_MOUSE
Organism:	Mus musculus
Length:	260 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLO2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|66911967 - gi\|66911967\|gb\|AAH97301.1\| Hagh protein [Rattus norvegicus]	248.0	[0..1]	[260..45]
gi\|74227220 - gi\|74227220\|dbj\|BAE38377.1\| unnamed protein product [Mus musculus]	247.0	[0..1]	[260..1]
gi\|80477642, gi\|... - gi\|80477642\|gb\|AAI08581.1\| MGC131075 protein [Xenopus laevis], gi\|148234718\|ref\|NP_001089873.1\| hypo...	246.0	[0..1]	[260..1]
GLO2_CHICK - Hydroxyacylglutathione hydrolase, mitochondrial OS=Gallus gallus GN=HAGH PE=2 SV=1	245.0	[0..1]	[260..51]
gi\|73959572 - gi\|73959572\|ref\|XP_537013.2\| PREDICTED: similar to hydroxyacyl glutathione hydrolase [Canis familiar...	244.0	[0..1]	[260..50]
GLO2_BOVIN - Hydroxyacylglutathione hydrolase, mitochondrial OS=Bos taurus GN=HAGH PE=2 SV=3	243.0	[0..1]	[260..49]
HAGH - hydroxyacylglutathione hydrolase	243.0	[0..1]	[260..49]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVELLPALT DNYMYLIIDE DTQEAAIVDP VQPQKVIEAA KKHHVKLTTV LTTHHHWDHA  60
   61 GGNEKLVKLE PGLKVYGGDD RIGALTHKVT HLSTLQVGSL SVKCLSTPCH TSGHICYFVS 120
  121 KPGSSEPSAV FTGDTLFVAG CGKFYEGTAD EMYKALLEVL GRLPPDTKVY CGHEYTVNNL 180
  181 KFARHVEPGN AAIQEKLAWA KEKYAIGEPT VPSTLAEEFT YNPFMRVKEK TVQQHAGETD 240
  241 PVTTMRAIRR EKDQFKVPRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.154902
Match:	1qh3A
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacylglutathione hydrolase activity	3.53012507604564	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
binding	0.900972948435178	bayes_pls_golite062009
thiolester hydrolase activity	0.802604883362264	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: