YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF22_MOUSE
Organism:	Mus musculus
Length:	162 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF22_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|60829861 - gi\|60829861\|gb\|AAX36897.1\| fibroblast growth factor 7 [synthetic construct]	204.0	[0..15]	[161..46]
FGF7_PONPY - Keratinocyte growth factor precursor - Pongo pygmaeus (Orangutan) FGF7_PONAB - Fibroblast growth factor 7 OS=Pongo abelii GN=FGF7 PE=2 SV=1 FGF7 - fibroblast growth factor 7 (keratinocyte growth factor) gi\|109081066 - gi\|109081066\|ref\|XP_001113805.1\| PREDICTED: similar to Keratinocyte growth factor precursor (KGF) (F... gi\|61356080 - gi\|61356080\|gb\|AAX41206.1\| fibroblast growth factor 7 [synthetic construct] gi\|114656948, gi... - gi\|114656950\|ref\|XP_001167319.1\| PREDICTED: fibroblast growth factor 7 isoform 3 [Pan troglodytes], ...	203.0	[0..15]	[161..46]
FGF7_SHEEP - Fibroblast growth factor 7 OS=Ovis aries GN=FGF7 PE=2 SV=1	201.0	[0..15]	[161..46]
FGF7_CEREL - Fibroblast growth factor 7 OS=Cervus elaphus GN=FGF7 PE=2 SV=1 gi\|119902623 - gi\|119902623\|ref\|XP_874109.2\| PREDICTED: similar to keratinocyte growth factor FGF-7 [Bos taurus]	201.0	[0..15]	[161..46]
FGF7_CANLF - Fibroblast growth factor 7 OS=Canis lupus familiaris GN=FGF7 PE=2 SV=1	201.0	[0..15]	[161..46]
gi\|45383362, gi\|... - gi\|45383362\|ref\|NP_989730.1\| fibroblast growth factor 9 (glia-activating factor) [Gallus gallus], gi...	200.0	[0..15]	[161..40]
FGF9_PIG - Fibroblast growth factor 9 OS=Sus scrofa GN=FGF9 PE=2 SV=1	199.0	[0..7]	[161..37]
gi\|76631618, gi\|... - gi\|76631620\|ref\|XP_877779.1\| PREDICTED: similar to fibroblast growth factor 9 precursor isoform 2 [B...	198.0	[0..7]	[161..37]
FGF9_MOUSE - Glia-activating factor OS=Mus musculus GN=Fgf9 PE=2 SV=1	198.0	[0..7]	[161..37]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSRLWLGLA WLLLARAPGA PGGYPHLEGD VRWRRLFSST HFFLRVDLGG RVQGTRWRHG  60
   61 QDSIVEIRSV RVGTVVIKAV YSGFYVAMNR RGRLYGSRVY SVDCRFRERI EENGYNTYAS 120
  121 RRWRHRGRPM FLALDSQGIP RQGRRTRRHQ LSTHFLPVLV SS

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Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1nunA
Description:	Fibroblast growth factor-10, FGF10
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
growth factor activity	5.3375009176144	bayes_pls_golite062009
fibroblast growth factor receptor binding	5.32138222782692	bayes_pls_golite062009
receptor binding	5.0880099372051	bayes_pls_golite062009
binding	2.90110516688922	bayes_pls_golite062009
cytokine activity	1.96936504239383	bayes_pls_golite062009
protein binding	1.94397222237906	bayes_pls_golite062009
signal transducer activity	1.24692031673405	bayes_pls_golite062009
molecular transducer activity	1.24692031673405	bayes_pls_golite062009
nerve growth factor receptor binding	0.308245352535379	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: