YRC Public Data Repository - Protein Structure Prediction

Protein:	ISCU_MOUSE
Organism:	Mus musculus
Length:	168 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISCU_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|20381021 - gi\|20381021\|gb\|AAH28800.1\| Iscu protein [Mus musculus]	234.0	[0..3]	[168..1]
gi\|109497403, gi... - gi\|27666566\|ref\|XP_213811.1\| PREDICTED: similar to nitrogen fixation cluster-like [Rattus norvegicus...	230.0	[0..3]	[168..2]
gi\|109098615 - gi\|109098615\|ref\|XP_001103180.1\| PREDICTED: similar to iron-sulfur cluster assembly enzyme isoform I... gi\|149720512 - gi\|149720512\|ref\|XP_001501092.1\| PREDICTED: similar to ISCU2 [Equus caballus] gi\|114646776 - gi\|114646776\|ref\|XP_509343.2\| PREDICTED: similar to ISCU2 isoform 2 [Pan troglodytes] ENSCJAT00000029974 - null	228.0	[0..3]	[168..2]
gi\|117645092, gi... - gi\|157929172\|gb\|ABW03871.1\| iron-sulfur cluster scaffold homolog (E. coli) [synthetic construct], gi... ISCU - iron-sulfur cluster scaffold homolog (E. coli)	227.0	[0..3]	[168..2]
gi\|61834337, gi\|... - gi\|76639550\|ref\|XP_871683.1\| PREDICTED: similar to iron-sulfur cluster assembly enzyme isoform ISCU2...	227.0	[0..3]	[168..2]
gi\|114556689 - gi\|114556689\|ref\|XP_001149059.1\| PREDICTED: similar to ISCU2 [Pan troglodytes]	225.0	[0..3]	[168..2]
gi\|57105700 - gi\|57105700\|ref\|XP_534722.1\| PREDICTED: similar to nitrogen fixation cluster-like isoform 1 [Canis f...	221.0	[0..3]	[155..2]

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Predicted Domain #1

Region A:
Residues: [1-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAATGAGRL RRAASALLLR SPRLPARELS APARLYHKKV VDHYENPRNV GSLDKTSKNV  60
   61 GTGLVGAPAC GDVMKLQIQV DEKGKIVDAR FKTFGCGSAI ASSSLATEWV KGKTVEEALT 120
  121 IKNTDIAKEL CLPPVKLHCS MLAEDAIKAA LADYKLKQES KKEEPEKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.0
Match:	1q48A
Description:	Solution NMR Structure of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24. This protein is not apo, it is a model without zinc binding constr
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.626732820625785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: