YRC Public Data Repository - Protein Structure Prediction

Protein:	MANF_MOUSE
Organism:	Mus musculus
Length:	179 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MANF_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|114587110 - gi\|114587110\|ref\|XP_001169644.1\| PREDICTED: similar to arginine-rich protein [Pan troglodytes]	325.0	[0..2]	[179..69]
gi\|284164, gi\|178991 - gi\|284164\|pir\|\|S27956 arginine-rich protein - human, gi\|178991\|gb\|AAB08753.1\| arginine-rich protein ...	317.0	[0..2]	[179..57]
gi\|110625813, gi... - gi\|74227026\|dbj\|BAE38314.1\| unnamed protein product [Mus musculus], gi\|74204855\|dbj\|BAE20927.1\| unna... MANF_RAT - Mesencephalic astrocyte-derived neurotrophic factor OS=Rattus norvegicus GN=Manf PE=1 SV=1	317.0	[0..1]	[179..1]
gi\|30585119 - gi\|30585119\|gb\|AAP36832.1\| Homo sapiens arginine-rich, mutated in early stage tumors [synthetic cons...	314.0	[0..1]	[179..4]
MANF_BOVIN - Mesencephalic astrocyte-derived neurotrophic factor OS=Bos taurus GN=MANF PE=1 SV=2	310.0	[0..1]	[179..1]
gi\|73985638 - gi\|73985638\|ref\|XP_850540.1\| PREDICTED: similar to ARMET protein precursor (Arginine-rich protein) [...	307.0	[0..1]	[179..1]
gi\|28913725 - gi\|28913725\|gb\|AAH48616.1\| Armet protein [Mus musculus]	275.0	[0..23]	[179..9]

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Predicted Domain #1

Region A:
Residues: [1-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWATRGLAVA LALSVLPDSR ALRPGDCEVC ISYLGRFYQD LKDRDVTFSP ATIEEELIKF  60
   61 CREARGKENR LCYYIGATDD AATKIINEVS KPLAHHIPVE KICEKLKKKD SQICELKYDN 120
  121 QIDLSTVDLK KLRVKELKKI LDDWGEMCKG CAEKSDYIRK INELMPKYAP KAASARTDL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.15
Match:	1y02A
Description:	Crystal Structure of a FYVE-type domain from caspase regulator CARP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.561606449522564	bayes_pls_golite062009
receptor binding	0.177430744933542	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: