YRC Public Data Repository - Protein Structure Prediction

Protein:	PKHF2_MOUSE
Organism:	Mus musculus
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PKHF2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|109476116, gi... - gi\|34866158\|ref\|XP_342804.1\| PREDICTED: similar to Phafin 2 [Rattus norvegicus], gi\|171847385\|gb\|AAI...	183.0	[0..1]	[236..1]
gi\|123993467, gi... - gi\|124000437\|gb\|ABM87727.1\| pleckstrin homology domain containing, family F (with FYVE domain) membe... PLEKHF2 - pleckstrin homology domain containing, family F (with FYVE domain) member 2 gi\|55631052 - gi\|55631052\|ref\|XP_528194.1\| PREDICTED: similar to phafin 2; PH and FYVE domain-containing protein 2...	182.0	[0..1]	[236..1]
gi\|62901986 - gi\|62901986\|gb\|AAY18944.1\| DKFZp762A0711 [synthetic construct]	180.0	[0..2]	[236..26]
PKHF2_CHICK - Pleckstrin homology domain-containing family F member 2 OS=Gallus gallus GN=PLEKHF2 PE=2 SV=1	176.0	[0..1]	[230..1]
gi\|125983332, gi... - gi\|54643746\|gb\|EAL32489.1\| GA13242 [Drosophila pseudoobscura pseudoobscura], gi\|125983332\|ref\|XP_001... gi\|54643746\|gb\|E... - GA13242-PA [Drosophila pseudoobscura], GA13242 [Drosophila pseudoobscura pseudoobscura]	173.0	[0..1]	[248..1]
gi\|220949950, gi... - gi\|220959106\|gb\|ACL92096.1\| CG14782-PA [synthetic construct], gi\|220949950\|gb\|ACL87518.1\| CG14782-PA... FBpp0308661, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG14782 (CG14782, FBgn0025381). It is a prote...	172.0	[0..1]	[248..1]
gi\|62859343 - gi\|62859343\|ref\|NP_001016121.1\| hypothetical protein LOC548875 [Xenopus (Silurana) tropicalis]	171.0	[0..1]	[233..1]
gi\|58386265, gi\|... - gi\|58386265\|ref\|XP_314634.2\| ENSANGP00000000661 [Anopheles gambiae str. PEST], gi\|55240031\|gb\|EAA100...	168.0	[0..1]	[218..1]
PKHF2_DANRE - Pleckstrin homology domain-containing family F member 2 OS=Danio rerio GN=plekhf2 PE=2 SV=1	168.0	[0..1]	[229..1]

Back

Predicted Domain #1

Region A:
Residues: [1-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDRLANSEA NTRRISIVES CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP KARQFFLFND  60
   61 ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGELRNGW LIKTPTKSFA VYAATATEKS 120
  121 EWMNHINKCV TDLLSKSGKT PSNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.221849
Match:	2dfkA
Description:	No description for 2dfkA was found.

Predicted Domain #2

Region A:
Residues: [145-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAAVWVPDSE ATVCMRCQKA KFTPVNRRHH CRKCGFVVCG PCSEKRFLLP SQSSKPVRIC  60
   61 DFCYDLLSTG DMAACQPTRS DSYSQSLKSP LNDASDDDDD DDSSD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.65
Match:	1y02A
Description:	Crystal Structure of a FYVE-type domain from caspase regulator CARP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.05854342812855	bayes_pls_golite062009
protein binding	0.217217014069682	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: