YRC Public Data Repository - Protein Structure Prediction

Protein:	ISN1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	405 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISN1_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|38100607, gi\|... - gi\|39970977\|ref\|XP_366879.1\| hypothetical protein MG02955.4 [Magnaporthe grisea 70-15], gb\|EAA47712....	647.0	[0..21]	[405..27]
ISN1_NEUCR - IMP-specific 5'-nucleotidase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / D... ISN1_NEUCR - IMP-specific 5'-nucleotidase 1 OS=Neurospora crassa GN=isn-1 PE=3 SV=1	638.0	[0..15]	[405..15]
ISN1_GIBZE - IMP-specific 5'-nucleotidase 1 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31... ISN1_GIBZE - IMP-specific 5'-nucleotidase 1 OS=Gibberella zeae GN=ISN1 PE=3 SV=1	637.0	[0..1]	[405..1]
gi\|115386952, gi... - gi\|115386952\|ref\|XP_001210017.1\| IMP-specific 5'-nucleotidase 1 [Aspergillus terreus NIH2624], gi\|11...	615.0	[0..1]	[399..1]
gi\|67525529, gi\|... - gi\|67525529\|ref\|XP_660826.1\| hypothetical protein AN3222.2 [Aspergillus nidulans FGSC A4], ref\|XP_40... ISN1_EMENI - IMP-specific 5'-nucleotidase 1 OS=Emericella nidulans GN=isn1 PE=3 SV=1	608.0	[0..1]	[405..1]
ISN1_CANAL - IMP-specific 5'-nucleotidase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ISN1 PE=3 SV=1 ISN1_CANAL - IMP-specific 5'-nucleotidase 1 OS=Candida albicans GN=ISN1 PE=3 SV=1	600.0	[0..1]	[404..1]
gi\|151945773 - gi\|151945773\|gb\|EDN64014.1\| IMP 5'-nucleotidase [Saccharomyces cerevisiae YJM789] ISN1 - Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, ... gi\|190407473 - gi\|190407473\|gb\|EDV10740.1\| IMP 5'-Nucleotidase [Saccharomyces cerevisiae RM11-1a] gi\|207341101 - gi\|207341101\|gb\|EDZ69248.1\| YOR155Cp-like protein [Saccharomyces cerevisiae AWRI1631] ISN1_YEAST - IMP-specific 5'-nucleotidase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISN1 PE=1...	590.0	[0..1]	[401..1]
gi\|83768308 - gi\|83768308\|dbj\|BAE58447.1\| unnamed protein product [Aspergillus oryzae] gi\|169771959 - gi\|169771959\|ref\|XP_001820449.1\| hypothetical protein [Aspergillus oryzae RIB40]	588.0	[0..1]	[405..1]
ISN1_ASPFU - IMP-specific 5'-nucleotidase 1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / ... ISN1_ASPFU - IMP-specific 5'-nucleotidase 1 OS=Aspergillus fumigatus GN=isn1 PE=3 SV=1	579.0	[0..1]	[404..1]

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Predicted Domain #1

Region A:
Residues: [1-87]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASRYRVEYA LKQHRKDDFI EWIKGLLSVP FVLQAGTPSQ KLVTREKEQE TLERYAVILR  60
   61 DVEKLIEAHI QIVSEGGSYS QLKMLVP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [88-405]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SITIFWTPLP LVKAMYALEP KLCLAKRSFV APSFNDVRAI LGGAQLNYLA DNGLDMVSFD  60
   61 GDVTLYEDGQ PLLPDNPVIS RLIQLLSRGI YVIILTAAGY PSRTGQEYTD RFSGLLQAIE 120
  121 DSDLKDGQKR KLHVLGGESN YLFAYDPLHG LQWVDADSWM LPVMKTWPHD EILEILDTAE 180
  181 ETLRSCIQGL NIDAKIVRKE RSVGFVPSLG QKLRREQLEE AVLETQATLQ IRNFSVPFTA 240
  241 FNGGNDIWCD IGDKKLGVLC LQHFFNISHP SRCLHVGDQF LSAGNNDYKA RAAATTVWVS 300
  301 SPHETIEFLD YYFSFLKK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.29
Match:	2amyA
Description:	X-Ray Structure of Human Phosphomannomutase 2 (PMM2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.43937506049289	bayes_pls_golite062009
hydrolase activity	0.841258720575862	bayes_pls_golite062009
nucleic acid binding	0.640795347679712	bayes_pls_golite062009
DNA binding	0.469738330154661	bayes_pls_golite062009
binding	0.439671963279462	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: