YRC Public Data Repository - Protein Structure Prediction

Protein:	THI6_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	518 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI6_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|78195360, gi\|... - gi\|78224105\|ref\|YP_385852.1\| phosphomethylpyrimidine kinase [Geobacter metallireducens GS-15], gi\|78...	285.0	[0..8]	[486..23]
gi\|222054517, gi... - gi\|222054517\|ref\|YP_002536879.1\| phosphomethylpyrimidine kinase [Geobacter sp. FRC-32], gi\|221563806...	282.0	[0..8]	[481..23]
gi\|85081198 - gi\|85081198\|ref\|XP_956678.1\| hypothetical protein [Neurospora crassa OR74A] gi\|28917751, gi\|... - gi\|32403276\|ref\|XP_322251.1\| hypothetical protein [Neurospora crassa], gi\|28917751\|gb\|EAA27442.1\| hy...	277.0	[0..13]	[516..228]
THED_GEOSL, THIE... - Bifunctional protein thiED OS=Geobacter sulfurreducens GN=thiDE PE=3 SV=1, (P61422) Bifunctional thi... THIED_GEOSL - Thiamine biosynthesis bifunctional protein ThiED OS=Geobacter sulfurreducens (strain ATCC 51573 / DS...	276.0	[0..8]	[482..23]
gi\|88915753, gi\|... - gi\|88937500\|ref\|ZP_01143064.1\| Thiamine monophosphate synthase:Phosphomethylpyrimidine kinase [Geoba...	275.0	[0..8]	[481..23]
gi\|49093108, gi\|... - gi\|67526841\|ref\|XP_661482.1\| hypothetical protein AN3878.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	275.0	[0..6]	[508..4]
gi\|38110813, gi\|... - gi\|39977091\|ref\|XP_369933.1\| hypothetical protein MGG_06448 [Magnaporthe grisea 70-15], gb\|EAA56477....	265.0	[0..2]	[516..4]
gi\|46125773, gi\|... - gi\|46125773\|ref\|XP_387440.1\| hypothetical protein FG07264.1 [Gibberella zeae PH-1], gi\|42555019\|gb\|E...	260.0	[0..2]	[518..6]
gi\|71741405, gi\|... - gi\|71838179\|ref\|ZP_00677940.1\| Thiamine monophosphate synthase:Phosphomethylpyrimidine kinase [Pelob...	259.0	[0..8]	[489..23]
gi\|95133247, gi\|... - gi\|95930767\|ref\|ZP_01313500.1\| Phosphomethylpyrimidine kinase [Desulfuromonas acetoxidans DSM 684], ...	258.0	[0..8]	[481..29]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRQIDYSLY LVTSSSLIAP GSTIERQVEE GILGGVTLVQ HREKDISTKC FVERAKRLSE  60
   61 ICKKYDVPFL INDRIDVALA VGADGVHIGQ DDMDCALARK ILGDDAIIGV STNNIEEIEK 120
  121 AAADGADYVG IGSIYETNTK DVKDRLIGIT GLRKILEHVS KMHCQLGTVA IAGLNSSNIQ 180
  181 RVIYLSEANG KRIDGIALVS AIMCSITPRE TAKELRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.69897
Match:	1g4tA
Description:	Thiamin phosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thiamin-phosphate diphosphorylase activity	5.90476603396884	bayes_pls_golite062009
phosphomethylpyrimidine kinase activity	1.96653650813022	bayes_pls_golite062009
catalytic activity	1.94308403509017	bayes_pls_golite062009
transferase activity	1.66762065968825	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.73172690404654	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.429889467826441	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [218-518]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIATPPCFAQ ARSSLTTPKD LLNQIPAALQ KLKDFTPLIH HLTNAVAKNF SANVTLAAYG  60
   61 SPTMGESYDE VADFAKAPGA LVLNIGILEN TKTYIHAAQV NNDLARPVIL DPVAVGATTA 120
  121 RSKVINTLLN YAYYDIIKGN EGEIMNLAGE QGLMRGVDSI SQHTLAARIT AVHRLAVERR 180
  181 CVVAMSGAVD VISDGNSTYV IKNGNPLLGQ ITASGCSLGS VMGVTASICQ NDKLLAAITA 240
  241 TLLYNIASEL AVEAKNSCGD LLVQGPGTFI PIFVDKLHQL INETIKGNVD WIERAKLEKA 300
  301 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1v8aA
Description:	Structure of Hydroxyethylthiazole kinase protein from pyrococcus horikoshii OT3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphomethylpyrimidine kinase activity	3.972577109569	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	2.29466565429735	bayes_pls_golite062009
kinase activity	2.28531824242987	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.27980720248925	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
hydroxyethylthiazole kinase activity	1.28568044601242	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	1.27602595951972	bayes_pls_golite062009
carbohydrate kinase activity	1.12876288824319	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.673555832721854	bayes_pls_golite062009
pyridoxal kinase activity	0.217863391052366	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: