YRC Public Data Repository - Protein Structure Prediction

Protein:	PSME1_MOUSE
Organism:	Mus musculus
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSME1_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|76688867 - gi\|76688867\|ref\|XP_869674.1\| PREDICTED: similar to amine oxidase, copper containing 2 isoform b isof...	398.0	[0..2]	[248..3]
gi\|54695640 - gi\|54695640\|gb\|AAV38192.1\| proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) [syn...	354.0	[0..2]	[249..3]
tr\|G3HLZ2\|G3HLZ2... - Proteasome activator complex subunit 3 OS=Cricetulus griseus GN=I79_011736 PE=4 SV=1 gi\|58476513, gi\|... - gi\|58865366\|ref\|NP_001011894.1\| proteasome (prosome, macropain) activator subunit 3 [Rattus norvegic... PSME3_MOUSE - Proteasome activator complex subunit 3 OS=Mus musculus GN=Psme3 PE=1 SV=1 PSME3_PIG - Proteasome activator complex subunit 3 OS=Sus scrofa GN=PSME3 PE=2 SV=1 tr\|F6QVK5\|F6QVK5... - Uncharacterized protein OS=Equus caballus OX=9796 GN=PSME3 PE=4 SV=1 PSME3_MACFA - Proteasome activator complex subunit 3 OS=Macaca fascicularis GN=PSME3 PE=2 SV=1 PSME3 - proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) gi\|123982054, gi... - gi\|123996883\|gb\|ABM86043.1\| proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) [sy... gi\|73965638, gi\|... - gi\|73965646\|ref\|XP_857850.1\| PREDICTED: similar to proteaseome (prosome, macropain) 28 subunit, 3 (p... gi\|76688859 - gi\|76688859\|ref\|XP_592707.2\| PREDICTED: similar to proteaseome (prosome, macropain) 28 subunit, 3 (p...	353.0	[0..2]	[249..3]
PSME3_PONPY - Proteasome activator complex subunit 3 - Pongo pygmaeus (Orangutan) PSME3_PONAB - Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1	353.0	[0..2]	[249..3]
gi\|49456449 - gi\|49456449\|emb\|CAG46545.1\| PSME3 [Homo sapiens]	352.0	[0..2]	[249..3]
gi\|73965644 - gi\|73965644\|ref\|XP_537633.2\| PREDICTED: similar to proteasome activator subunit 3 isoform 2 isoform ...	351.0	[0..2]	[249..3]
gi\|61098214, gi\|... - gi\|61098214\|ref\|NP_058960.2\| protease (prosome, macropain) 28 subunit, alpha [Rattus norvegicus], gi...	349.0	[0..1]	[249..1]
PSME3_CHICK - Proteasome activator complex subunit 3 OS=Gallus gallus GN=PSME3 PE=1 SV=1	348.0	[0..2]	[249..3]

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Predicted Domain #1

Region A:
Residues: [1-97]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP  60
   61 LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.522879
Match:	1avoA
Description:	Proteasome activator reg(alpha)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [98-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPPCGPVNCN EKIVVLLQRL KPEIKDVTEQ LNLVTTWLQL QIPRIEDGNN FGVAVQEKVF  60
   61 ELMTNLHTKL EGFHTQISKY FSERGDAVAK AAKQPHVGDY RQLVHELDEA EYQEIRLMVM 120
  121 EIRNAYAVLY DIILKNFEKL KKPRGETKGM IY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.0
Match:	1avoB
Description:	PROTEASOME ACTIVATOR REG(ALPHA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
proteasome activator activity	5.59640159138257	bayes_pls_golite062009
proteasome regulator activity	4.54794772700869	bayes_pls_golite062009
binding	2.01347128874017	bayes_pls_golite062009
protein binding	0.834565661881528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: