YRC Public Data Repository - Protein Structure Prediction

Protein:	SIX2_MOUSE
Organism:	Mus musculus
Length:	296 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIX2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|76669856 - gi\|76669856\|ref\|XP_587683.2\| PREDICTED: similar to Six2 [Bos taurus]	207.0	[0..1]	[296..1]
gi\|791086 - gi\|791086\|emb\|CAA56584.1\| six2 [Mus musculus]	200.0	[0..7]	[296..32]
gi\|73970120 - gi\|73970120\|ref\|XP_538478.2\| PREDICTED: similar to Homeobox protein SIX2 (Sine oculis homeobox homol...	198.0	[0..1]	[296..188]
gi\|114577224 - gi\|114577224\|ref\|XP_515444.2\| PREDICTED: sine oculis homeobox homolog 2 [Pan troglodytes]	198.0	[0..1]	[296..1]
gi\|208967416, gi... - gi\|61357734\|gb\|AAX41436.1\| sine oculis homeobox-like 2 [synthetic construct], gi\|208967416\|dbj\|BAG73... ENSCJAT00000001330 - null HGNC:10888\|MIM:6... - homeobox 2 SIX2 - SIX homeobox 2 gi\|55595642 - gi\|55595642\|ref\|XP_515444.1\| PREDICTED: hypothetical protein XP_515444 [Pan troglodytes]	197.0	[0..1]	[296..1]
gi\|109102964 - gi\|109102964\|ref\|XP_001108575.1\| PREDICTED: similar to Homeobox protein SIX2 (Sine oculis homeobox h...	196.0	[0..3]	[296..1]
gi\|220678458, gi... - gi\|50927148\|gb\|AAH79528.1\| Sine oculis homeobox homolog 2.1 [Danio rerio], gi\|220678458\|emb\|CAX12909...	194.0	[0..1]	[296..1]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR  60
   61 GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 120
  121 IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 180
  181 AAEAKERENS ENSN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.30103
Match:	1cqtA
Description:	Oct-1 POU Homeodomain; Oct-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [195-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSHNPLASS LNGSGKSVLG SSEDEKTPSG TPDHSSSSPA LLLSPPPPPG LPSLHSLGHP  60
   61 PGPSAVPVPV PGGGGADPLQ HHHSLQDSIL NPMSANLVDL GS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits