YRC Public Data Repository - Protein Structure Prediction

Protein:	CLSA_YERPA
Organism:	Yersinia pestis Antiqua
Length:	486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLSA_YERPA.

Description	E-value	Query Range	Subject Range
CLS_YERPS - Cardiolipin synthase OS=Yersinia pseudotuberculosis GN=cls PE=3 SV=1 CLSA_YERPB - Cardiolipin synthase A OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=clsA PE=3 SV=1 CLSA_YERPS - Cardiolipin synthase A OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=clsA PE=3 SV=1	0.0	[1..486]	[1..486]
gi\|22125925, gi\|... - gi\|22125925\|ref\|NP_669348.1\| cardiolipin synthetase [Yersinia pestis KIM], gi\|21958864\|gb\|AAM85599.1... gi\|45441787, gi\|... - gi\|45441787\|ref\|NP_993326.1\| cardiolipin synthetase [Yersinia pestis biovar Microtus str. 91001], gi...	0.0	[1..486]	[8..493]
gi\|77960752 - gi\|77960752\|ref\|ZP_00824610.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	0.0	[1..486]	[1..486]
gi\|77977781, gi\|... - gi\|77977781\|ref\|ZP_00833221.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	0.0	[1..486]	[1..486]
gi\|77972671, gi\|... - gi\|77972671\|ref\|ZP_00828231.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	0.0	[1..486]	[1..486]
gi\|77957084, gi\|... - gi\|77957084\|ref\|ZP_00821150.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	0.0	[1..486]	[1..486]
CLSA_PECAS - Cardiolipin synthase A OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=clsA PE=3... CLS_ERWCT - Cardiolipin synthase OS=Erwinia carotovora subsp. atroseptica GN=cls PE=3 SV=1	0.0	[1..486]	[1..486]
gi\|205321911, gi... - gi\|205321911\|gb\|EDZ09750.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Sain... CLS_SALPB - Cardiolipin synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=cls PE=3 SV=1 CLS_SALCH - Cardiolipin synthetase OS=Salmonella choleraesuis GN=cls PE=3 SV=1 CLS_SALCH - Cardiolipin synthase OS=Salmonella choleraesuis GN=cls PE=3 SV=1 CLSA_SALA4 - Cardiolipin synthase A OS=Salmonella agona (strain SL483) GN=clsA PE=3 SV=1 CLSA_SALSV - Cardiolipin synthase A OS=Salmonella schwarzengrund (strain CVM19633) GN=clsA PE=3 SV=1 gi\|238911869 - gi\|238911869\|ref\|ZP_04655706.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... gi\|194459023, gi... - gi\|194472659\|ref\|ZP_03078643.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... CLSA_SALHS - Cardiolipin synthase A OS=Salmonella heidelberg (strain SL476) GN=clsA PE=3 SV=1 CLSA_SALCH - Cardiolipin synthase A OS=Salmonella choleraesuis (strain SC-B67) GN=clsA PE=3 SV=1 CLSA_SALEP - Cardiolipin synthase A OS=Salmonella enteritidis PT4 (strain P125109) GN=clsA PE=3 SV=1 gi\|204322943, gi... - gi\|204927601\|ref\|ZP_03218802.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... CLS_SALTY - Cardiolipin synthetase OS=Salmonella typhimurium GN=cls PE=3 SV=1 CLSA_SALDC - Cardiolipin synthase A OS=Salmonella dublin (strain CT_02021853) GN=clsA PE=3 SV=1 CLS_SALTI - Cardiolipin synthetase OS=Salmonella typhi GN=cls PE=3 SV=1 gi\|197264155, gi... - gi\|197264155\|ref\|ZP_03164229.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... gi\|168241319, gi... - gi\|205339313\|gb\|EDZ26077.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Heid... gi\|197289191, gi... - gi\|197289191\|gb\|EDY28558.1\| cardiolipin synthetase (Cardiolipin synthase) [Salmonella enterica subsp... gi\|205335432, gi... - gi\|205335432\|gb\|EDZ22196.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Kent... gi\|167994645, gi... - gi\|205327527\|gb\|EDZ14291.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar 4,[5... CLSA_SALNS - Cardiolipin synthase A OS=Salmonella newport (strain SL254) GN=clsA PE=3 SV=1 gi\|168819563, gi... - gi\|205343630\|gb\|EDZ30394.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Welt... gi\|168462786, gi... - gi\|195634248\|gb\|EDX52600.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Newp... gi\|168260038, gi... - gi\|205350852\|gb\|EDZ37483.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Hada... gi\|29137716, gi\|... - gi\|29142087\|ref\|NP_805429.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Typ... gi\|16760142 - gi\|16760142\|ref\|NP_455759.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar Typ... CLSA_SALPB - Cardiolipin synthase A OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=clsA PE=3 SV=1 CLSA_SALTI - Cardiolipin synthase A OS=Salmonella typhi GN=clsA PE=3 SV=1 CLSA_SALTY - Cardiolipin synthase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=clsA PE=3 ... gi\|213580905 - gi\|213580905\|ref\|ZP_03362731.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... CLS_SALTY - Cardiolipin synthase OS=Salmonella typhimurium GN=cls PE=3 SV=1 lcl\|NC_016856.1_... - [gene=cls] [protein=cardiolipin synthetase] [protein_id=YP_005237666.1] [location=1843557..1845017] gi\|213426178 - gi\|213426178\|ref\|ZP_03358928.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... gi\|213419456 - gi\|213419456\|ref\|ZP_03352522.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... gi\|213163083 - gi\|213163083\|ref\|ZP_03348793.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... CLSA_SALPC - Cardiolipin synthase A OS=Salmonella paratyphi C (strain RKS4594) GN=clsA PE=3 SV=1 gi\|214002687 - gi\|214002687\|ref\|ZP_03413422.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ... gi\|213650439 - gi\|213650439\|ref\|ZP_03380492.1\| cardiolipin synthetase [Salmonella enterica subsp. enterica serovar ...	0.0	[1..486]	[1..486]
CLSA_SODGM - Cardiolipin synthase A OS=Sodalis glossinidius (strain morsitans) GN=clsA PE=3 SV=1	0.0	[1..486]	[1..486]
gi\|902467 - gi\|902467\|gb\|AAB60144.1\| cardiolipin synthase	0.0	[1..486]	[1..486]

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Predicted Domain #1

Region A:
Residues: [1-93]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTFYTVISW LSVFGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLSFGE  60
   61 LHLGKRRAER AKAMWPSTAR WLSELKECQH IFA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [94-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSNSEVASPL FQLCERRQGI NGVKGNQLQL LTTTDDTLKA LVRDIELARH NIEMVFYIWQ  60
   61 PGGLVDQVAE SLMAAARRGV HCRLLLDSAG SKQFFRSPYP AMMRNAGIEV VEALKVNVFR 120
  121 MFLRRMDLRQ HRKIVLIDNY VAYTGSMNMV DPRFFKQDAG VGQWIDMMAR MEGPVATTLG 180
  181 IVYACDWEIE TGKRILPPPP DANIMPFEEE TGHTIQVIAS GPGFPEEMIH QALLTAVYAA 240
  241 REQLIMTTPY FVPSDDLLHA ICTAAQRGVD VSIIVPREND SMMVRWASRA FFTELLNAGV 300
  301 KIYQFEGGLL HSKSVLVDGQ LSLVGTVNLD MRSLWLNFEI TLVIDDDGFG ADLAQVQDDY 360
  361 IARSALLDGE RWNKRPLWHR VTERLFYFFS PLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.69897
Match:	1xdoA
Description:	Crystal Structure of Escherichia coli Polyphosphate Kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoric diester hydrolase activity	1.55477881010087	bayes_pls_golite062009
catalytic activity	1.29236214516383	bayes_pls_golite062009
binding	0.66572565048579	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.486367378916393	bayes_pls_golite062009
protein binding	0.162885453822356	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: