YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|21740005
Organism:	Homo sapiens
Length:	149 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21740005.

Description	E-value	Query Range	Subject Range
gi\|94394826, gi\|... - gi\|94395869\|ref\|XP_992569.1\| PREDICTED: similar to HESB like domain containing 2 [Mus musculus], gi\|...	3.0E-46	[1..149]	[24..171]
gi\|73946570 - gi\|73946570\|ref\|XP_849435.1\| PREDICTED: similar to HESB like domain containing 2 [Canis familiaris]	2.0E-45	[2..149]	[113..260]
gi\|37197683, gi\|... - gi\|37678941\|ref\|NP_933550.1\| hypothetical protein VV0757 [Vibrio vulnificus YJ016], gi\|37197683\|dbj\|...	6.0E-43	[43..149]	[1..107]
gi\|86145585, gi\|... - gi\|86145585\|ref\|ZP_01063915.1\| HesB family protein [Vibrio sp. MED222], gi\|85836556\|gb\|EAQ54682.1\| H... gi\|218321650, gi... - gi\|218708631\|ref\|YP_002416252.1\| HesB family protein [Vibrio splendidus LGP32], gi\|218321650\|emb\|CAV... gi\|84377461, gi\|... - gi\|84387616\|ref\|ZP_00990633.1\| HesB family protein [Vibrio splendidus 12B01], gi\|84377461\|gb\|EAP9432...	8.0E-43	[43..149]	[1..107]
gi\|27360021, gi\|... - gi\|27363904\|ref\|NP_759432.1\| HesB family protein [Vibrio vulnificus CMCP6], gi\|27360021\|gb\|AAO08959....	1.0E-42	[43..149]	[1..107]
gi\|28897372, gi\|... - gi\|28897372\|ref\|NP_796977.1\| HesB family protein [Vibrio parahaemolyticus RIMD 2210633], gi\|28805584... gi\|28805584 - gi\|28805584\|dbj\|BAC58861.1\| HesB family protein [Vibrio parahaemolyticus RIMD 2210633]	1.0E-42	[43..149]	[1..107]
gi\|126208405, gi... - gi\|126208405\|ref\|YP_001053630.1\| iron-binding protein IscA [Actinobacillus pleuropneumoniae L20], gi... gi\|190150256, gi... - gi\|190150256\|ref\|YP_001968781.1\| iron-binding protein IscA [Actinobacillus pleuropneumoniae serovar ... gi\|165976348, gi... - gi\|165976348\|ref\|YP_001651941.1\| iron-binding protein [Actinobacillus pleuropneumoniae serovar 3 str... gi\|32034039 - gi\|32034039\|ref\|ZP_00134283.1\| COG0316: Uncharacterized conserved protein [Actinobacillus pleuropneu...	2.0E-42	[43..149]	[1..107]
ISCA1_RAT - Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Rattus norvegicus GN=Isca1 PE=2 SV=1	2.0E-42	[21..149]	[1..129]

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Predicted Domain #1

Region A:
Residues: [1-149]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEKLRRPTFG PRHRGAGTAK MSASLVRATV RAVSKRKLQP TRAALTLTPS AVNKIKQLLK  60
   61 DKPEHVGVKV GVRTRGCNGL SYTLEYTKTK GDSDEEVIQD GVRVFIEKKA QLTLLGTEMD 120
  121 YVEDKLSSEF VFNNPNIKGT CGCGESFNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1s98A
Description:	E.coli IscA crystal structure to 2.3 A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2 iron, 2 sulfur cluster binding	1.80248983815833	bayes_pls_golite062009
iron-sulfur cluster binding	1.47577968990921	bayes_pls_golite062009
metal cluster binding	1.47577968990921	bayes_pls_golite062009
binding	0.287940710403657	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: