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View Structure Prediction Details

Protein: NMNAT1
Organism: Homo sapiens
Length: 279 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMNAT1.

Description E-value Query
Range
Subject
Range
gi|21730493, gi|... - gi|21730493|pdb|1KKU|A Chain A, Crystal Structure Of Nuclear Human Nicotinamide Mononucleotide Adeny...
2.0E-75 [1..279] [1..279]
gi|11596129, gi|... - gi|11596129|gb|AAG38490.1|AF260927_1 D4Cole1e [Mus musculus], gi|10442021|gb|AAG17286.1|AF260925_1 D...
1.0E-72 [1..278] [81..359]
gi|83025119, gi|... - gi|83025119|ref|NP_001032645.1| nicotinamide nucleotide adenylyltransferase 1 [Rattus norvegicus], g...
3.0E-71 [1..278] [1..279]
NMNA1_BOVIN - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Bos taurus GN=NMNAT1 PE=2 SV=1
9.0E-68 [1..278] [1..280]

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Predicted Domain #1
Region A:
Residues: [1-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENSEKTEVV LLACGSFNPI TNMHLRLFEL AKDYMNGTGR YTVVKGIISP VGDAYKKKGL  60
   61 IPAYHRVIMA ELATKNSKWV EVDTWESLQK EWKETLKVLR HHQEKLEASD CDHQQNSPTL 120
  121 ERPGRKRKWT ETQDSSQKKS LEPKTKAVPK VKLLCGADLL ESFAVPNLWK SEDITQIVAN 180
  181 YGLICVTRAG NDAQKFIYES DVLWKHRSNI HVVNEWIAND ISSTKIRRAL RRGQSIRYLV 240
  241 PDLVQEYIEK HNLYSSESED RNAGVILAPL QRNTAEAKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.0
Match: 1kkuA
Description: Nicotinamide mononucleotide (NMN) adenylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nicotinate-nucleotide adenylyltransferase activity 2.94996967804011 bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity 2.8149071156304 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 2.54008423253828 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 2.54008423253828 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 2.52910114154477 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
ligase activity 1.92894388839884 bayes_pls_golite062009
binding 1.11291710031577 bayes_pls_golite062009
adenylyltransferase activity 1.08055019963499 bayes_pls_golite062009
nucleic acid binding 0.623161608923414 bayes_pls_golite062009
nucleotidyltransferase activity 0.564359271862248 bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity 0.454904507512502 bayes_pls_golite062009
pantoate-beta-alanine ligase activity 0.282286652169846 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle