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View Structure Prediction Details

Protein: HNRNPM
Organism: Homo sapiens
Length: 730 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPM.

Description E-value Query
Range
Subject
Range
gi|73986955 - gi|73986955|ref|XP_854270.1| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein M isoform...
1.0E-71 [17..730] [17..730]
gi|187281, gi|479852 - pir||S35532 hnRNA-binding protein M4 - human, gi|187281|gb|AAA36192.1| M4 protein
1.0E-70 [20..730] [19..729]
HNRPM_MOUSE - Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3
2.0E-70 [15..730] [15..729]
gi|114675110 - gi|114675110|ref|XP_001159225.1| PREDICTED: heterogeneous nuclear ribonucleoprotein M isoform 16 [Pa...
9.0E-69 [15..730] [15..715]

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Predicted Domain #1
Region A:
Residues: [1-187]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGVEAAAE VAATEIKMEE ESGAPGVPSG NGAPGPKGEG ERPAQNEKRK EKNIKRGGNR  60
   61 FEPYANPTKR YRAFITNIPF DVKWQSLKDL VKEKVGEVTY VELLMDAEGK SRGCAVVEFK 120
  121 MEESMKKAAE VLNKHSLSGR PLKVKEDPDG EHARRAMQKV MATTGGMGMG PGGPGMITIP 180
  181 PSILNNP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.09691
Match: 1welA
Description: Solution structure of RNA binding domain in NP_006038
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [188-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIPNEIIHAL QAGRLGSTVF VANLDYKVGW KKLKEVFSMA GVVVRADILE DKDGKSRGIG  60
   61 TVTFEQSIEA VQAISMFNGQ LLFDRPMHVK MDERALPKGD FFPPER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2do0A
Description: No description for 2do0A was found.

Predicted Domain #3
Region A:
Residues: [294-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQQLPHGLGG IGMGLGPGGQ PIDANHLNKG IGMGNIGPAG MGMEGIGFGI NKMGGMEGPF  60
   61 GGGMENMGRF GSGMN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.97
Match: 1p9hA
Description: CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [369-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRINEILSN ALKRGEIIAK QGGGGGGGSV PGIERMGPGI DRLGGAGMER MGAGLGHGMD  60
   61 RVGSEIERMG LVMDRMGSVE RMGSGIERMG PLGLDHMASS IERMGQTMER IGSGVERMGA 120
  121 GMGFGLERMA APIDRVGQTI ERMGSGVERM GPAIERMGLS MERMVPAGMG AGLERMGPVM 180
  181 DRMATGLERM GANNLERMGL ERMGANSLER MGLERMGANS LERMGPAMGP ALGAGIERMG 240
  241 LAMGGGGGAS FDRAIEMERG NFGGSFAGSF GGAGGHAPG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.13
Match: 2efkA
Description: No description for 2efkA was found.

Predicted functions:

Term Confidence Notes
binding 2.18655500954725 bayes_pls_golite062009
protein binding 1.03745306645514 bayes_pls_golite062009
catalytic activity 0.00204734407654122 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [648-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VARKACQIFV RNLPFDFTWK MLKDKFNECG HVLYADIKME NGKSKGCGVV KFESPEVAER  60
   61 ACRMMNGMKL SGREIDVRID RNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 2dgvA
Description: No description for 2dgvA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle