YRC Public Data Repository - Protein Structure Prediction

Protein:	BUB1
Organism:	Homo sapiens
Length:	1085 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUB1.

Description	E-value	Query Range	Subject Range
gi\|2981233 - gi\|2981233\|gb\|AAC06259.1\| mitotic checkpoint kinase Bub1 [Homo sapiens]	745.0	[0..1]	[1085..1]
gi\|114579502, gi... - gi\|114579504\|ref\|XP_515685.2\| PREDICTED: BUB1 budding uninhibited by benzimidazoles 1 homolog [Pan t...	741.0	[0..1]	[1085..1]
gi\|76628545 - gi\|76628545\|ref\|XP_592682.2\| PREDICTED: similar to mitotic checkpoint protein kinase [Bos taurus]	672.0	[0..6]	[1085..5]
gi\|7513785, gi\|2... - gi\|7513785\|pir\|\|T31004 probable mitotic checkpoint control protein kinase BUB1 - mouse (fragment), g...	672.0	[0..1]	[1085..45]
gi\|157817678, gi... - gi\|62645833\|ref\|XP_215849.3\| PREDICTED: similar to budding uninhibited by benzimidazoles 1 homolog [...	634.0	[0..1]	[1085..1]
gi\|118403495, gi... - gi\|118403495\|ref\|NP_001072830.1\| budding uninhibited by benzimidazoles 1 [Xenopus (Silurana) tropica...	516.0	[0..1]	[1085..1]
gi\|13122446 - gi\|13122446\|gb\|AAK12628.1\|AF119789_1 protein kinase Bub1 [Xenopus laevis]	504.0	[0..1]	[1085..1]

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Predicted Domain #1

Region A:
Residues: [1-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK  60
   61 KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA 120
  121 VLQRGIQNQA EPREFLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN 180
  181 NMACISKNQG SELSG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.89
Match:	2ooeA
Description:	No description for 2ooeA was found.

Predicted Domain #2

Region A:
Residues: [196-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VISSACDKES NMERRVITIS KSEYSVHSSL ASKVDVEQVV MYCKEKLIRG ESEFSFEELR  60
   61 AQKYNQRRKH EQW

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [269-515]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNEDRHYMKR KEANAFEEQL LKQKMDELHK KLHQVVETSH EDLPASQERS EVNPARMGPS  60
   61 VGSQQELRAP CLPVTYQQTP VNMEKNPREA PPVVPPLANA ISAALVSPAT SQSIAPPVPL 120
  121 KAQTVTDSMF AVASKDAGCV NKSTHEFKPQ SGAEIKEGCE THKVANTSSF HTTPNTSLGM 180
  181 VQATPSKVQP SPTVHTKEAL GFIMNMFQAP TLPDISDDKD EWQSLDQNED AFEAQFQKNV 240
  241 RSSGAWG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.05
Match:	1h1kI
Description:	THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [516-1085]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNKIISSLSS AFHVFEDGNK ENYGLPQPKN KPTGARTFGE RSVSRLPSKP KEEVPHAEEF  60
   61 LDDSTVWGIR CNKTLAPSPK SPGDFTSAAQ LASTPFHKLP VESVHILEDK ENVVAKQCTQ 120
  121 ATLDSCEENM VVPSRDGKFS PIQEKSPKQA LSSHMYSASL LRLSQPAAGG VLTCEAELGV 180
  181 EACRLTDTDA AIAEDPPDAI AGLQAEWMQM SSLGTVDAPN FIVGNPWDDK LIFKLLSGLS 240
  241 KPVSSYPNTF EWQCKLPAIK PKTEFQLGSK LVYVHHLLGE GAFAQVYEAT QGDLNDAKNK 300
  301 QKFVLKVQKP ANPWEFYIGT QLMERLKPSM QHMFMKFYSA HLFQNGSVLV GELYSYGTLL 360
  361 NAINLYKNTP EKVMPQGLVI SFAMRMLYMI EQVHDCEIIH GDIKPDNFIL GNGFLEQDDE 420
  421 DDLSAGLALI DLGQSIDMKL FPKGTIFTAK CETSGFQCVE MLSNKPWNYQ IDYFGVAATV 480
  481 YCMLFGTYMK VKNEGGECKP EGLFRRLPHL DMWNEFFHVM LNIPDCHHLP SLDLLRQKLK 540
  541 KVFQQHYTNK IRALRNRLIV LLLECKRSRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.154902
Match:	2h8hA
Description:	No description for 2h8hA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits