YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPA1L2
Organism:	Homo sapiens
Length:	320 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPA1L2.

Description	E-value	Query Range	Subject Range
IPI01022218, IPI... - Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 PE=4 SV=1, IPI:IPI01022218.1\|E... gi\|73996145 - gi\|73996145\|ref\|XP_856107.1\| PREDICTED: similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix... gi\|114695690 - gi\|114695690\|ref\|XP_001137220.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein A1 isoform 4 [Pa...	8.0E-59	[1..304]	[1..304]
gi\|87650, gi\|36102 - pir\|\|S02061 heterogeneous ribonuclear particle protein A1.beta - human, gi\|36102\|emb\|CAA29922.1\| unn...	1.0E-58	[1..302]	[1..302]
ROA1_RAT - Heterogeneous nuclear ribonucleoprotein A1 OS=Rattus norvegicus GN=Hnrnpa1 PE=1 SV=3	2.0E-58	[1..302]	[1..302]
gi\|114628933 - gi\|114628933\|ref\|XP_001146413.1\| PREDICTED: similar to Heterogeneous nuclear ribonucleoprotein A1 (H...	3.0E-58	[1..304]	[1..304]
gi\|74141832 - gi\|74141832\|dbj\|BAE40987.1\| unnamed protein product [Mus musculus]	5.0E-58	[1..302]	[1..302]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV  60
   61 TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH 120
  121 LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA 180
  181 LPKQEMASAS SSQR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.0
Match:	1l3kA
Description:	Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.950788308762215	bayes_pls_golite062009
nucleic acid binding	0.29562225149076	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [195-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRRGSGNFGG GRGDGFGGND NFGRGGNFSG RGGFGGSCGG GGYGGSGDGY NGFGNDGSNF  60
   61 GGGGSYNDFG NYNNQSSNFG PMKGGNFGGR SSGPYGGGGQ YFAKPQNQGG YGVSSSSSSY 120
  121 GSGRRF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.42
Match:	1jchA
Description:	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: