YRC Public Data Repository - Protein Structure Prediction

Protein:	ACTN1
Organism:	Homo sapiens
Length:	892 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACTN1.

Description	E-value	Query Range	Subject Range
gi\|73963351 - gi\|73963351\|ref\|XP_866940.1\| PREDICTED: similar to actinin, alpha 1 isoform 7 [Canis familiaris]	1.0E-89	[1..892]	[1..923]
ACTN1_RAT - Alpha-actinin-1 OS=Rattus norvegicus GN=Actn1 PE=1 SV=1	2.0E-89	[1..892]	[1..892]
ACTN1_MACFA - Alpha-actinin-1 OS=Macaca fascicularis GN=ACTN1 PE=2 SV=1	2.0E-89	[1..892]	[1..892]
ACTN1_BOVIN - Alpha-actinin-1 OS=Bos taurus GN=ACTN1 PE=2 SV=1	4.0E-89	[1..892]	[1..892]
gi\|625303, gi\|28334 - pir\|\|FAHUAA alpha-actinin 1 - human, gi\|28334\|emb\|CAA33803.1\| unnamed protein product [Homo sapiens]	5.0E-89	[1..892]	[1..892]
gi\|30585329, gi\|... - gi\|61373054\|gb\|AAX43966.1\| actinin alpha 1 [synthetic construct], gi\|61373051\|gb\|AAX43965.1\| actinin...	8.0E-89	[1..892]	[1..892]
ACTN1_MOUSE - Alpha-actinin-1 OS=Mus musculus GN=Actn1 PE=1 SV=1	3.0E-88	[1..892]	[1..892]

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Predicted Domain #1

Region A:
Residues: [1-892]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT QIENIEEDFR  60
   61 DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI ASKGVKLVSI GAEEIVDGNV 120
  121 KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC 180
  181 ALIHRHRPEL IDYGKLRKDD PLTNLNTAFD VAEKYLDIPK MLDAEDIVGT ARPDEKAIMT 240
  241 YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR 300
  301 VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE KCQLEINFNT LQTKLRLSNR PAFMPSEGRM 360
  361 VSDINNAWGC LEQVEKGYEE WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLRQK 420
  421 DYETATLSEI KALLKKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSP SVNARCQKIC 480
  481 DQWDNLGALT QKRREALERT EKLLETIDQL YLEYAKRAAP FNNWMEGAME DLQDTFIVHT 540
  541 IEEIQGLTTA HEQFKATLPD ADKERLAILG IHNEVSKIVQ TYHVNMAGTN PYTTITPQEI 600
  601 NGKWDHVRQL VPRRDQALTE EHARQQHNER LRKQFGAQAN VIGPWIQTKM EEIGRISIEM 660
  661 HGTLEDQLSH LRQYEKSIVN YKPKIDQLEG DHQLIQEALI FDNKHTNYTM EHIRVGWEQL 720
  721 LTTIARTINE VENQILTRDA KGISQEQMNE FRASFNHFDR DHSGTLGPEE FKACLISLGY 780
  781 DIGNDPQGEA EFARIMSIVD PNRLGVVTFQ AFIDFMSRET ADTDTADQVM ASFKILAGDK 840
  841 NYITMDELRR ELPPDQAEYC IARMAPYTGP DSVPGALDYM SFSTALYGES DL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1sjjA
Description:	Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits