YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPR
Organism:	Homo sapiens
Length:	633 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPR.

Description	E-value	Query Range	Subject Range
gi\|114554622 - gi\|114554622\|ref\|XP_513191.2\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein R [Pan t...	2.0E-66	[1..633]	[106..738]
gi\|55732180 - gi\|55732180\|emb\|CAH92794.1\| hypothetical protein [Pongo abelii] gi\|197102464 - gi\|197102464\|ref\|NP_001126631.1\| heterogeneous nuclear ribonucleoprotein R [Pongo abelii]	2.0E-66	[1..633]	[1..633]
gi\|108999072 - gi\|108999072\|ref\|XP_001111802.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein R [Macaca mulatt...	2.0E-65	[1..633]	[161..793]
gi\|74207436 - gi\|74207436\|dbj\|BAE30898.1\| unnamed protein product [Mus musculus]	2.0E-65	[1..633]	[1..632]
gi\|12655185, gi\|... - gi\|56203530\|emb\|CAI19027.1\| heterogeneous nuclear ribonucleoprotein R [Homo sapiens], gi\|156151394\|r... gi\|123997373, gi... - gi\|123997373\|gb\|ABM86288.1\| heterogeneous nuclear ribonucleoprotein R [synthetic construct], gi\|1239... ENSPTRT00000000644 - null	2.0E-65	[1..633]	[1..636]
gi\|62990189, gi\|... - gi\|62990189\|ref\|NP_783193.2\| heterogeneous nuclear ribonucleoprotein R [Rattus norvegicus], gi\|62471...	3.0E-65	[1..633]	[1..632]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL  60
   61 DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK 120
  121 GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [159-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQPGIGTEVF VGKIPRDLYE DELVPLFEKA GPIWDLRLMM DPLSGQNRGY AFITFCGKEA  60
   61 AQEAVKLCDS YEIRPGKHLG VCISVANNRL FVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	2dguA
Description:	No description for 2dguA was found.

Predicted Domain #3

Region A:
Residues: [252-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIPKNKTKEN ILEEFSKVTE GLVDVILYHQ PDDKKKNRGF CFLEYEDHKS AAQARRRLMS  60
   61 GKVKVWGNVV TVEWADPVEE PDPEVMAKVK VLFVRNLATT VTEEILEKSF SEFGKLERVK 120
  121 KLKDYAFVHF EDRGAAVKAM DEMNGKEIEG EEIEIVLAKP PDKKRKERQA ARQAS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.29
Match:	1cvjA
Description:	Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.787118623292657	bayes_pls_golite062009
nucleic acid binding	0.0269483316710413	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [427-633]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSTAYEDYYY HPPPRMPPPI RGRGRGGGRG GYGYPPDYYG YEDYYDDYYG YDYHDYRGGY  60
   61 EDPYYGYDDG YAVRGRGGGR GGRGAPPPPR GRGAPPPRGR AGYSQRGAPL GPPRGSRGGR 120
  121 GGPAQQQRGR GSRGSRGNRG GNVGGKRKAD GYNQPDSKRR QTNNQQNWGS QPIAQQPLQQ 180
  181 GGDYSGNYGY NNDNQEFYQD TYGQQWK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.69897
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: