YRC Public Data Repository - Protein Structure Prediction

Protein:	AREGB, AREG
Organism:	Homo sapiens
Length:	252 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AREGB, AREG.

Description	E-value	Query Range	Subject Range
gi\|114594252 - gi\|114594252\|ref\|XP_517224.2\| PREDICTED: similar to Amphiregulin precursor (AR) (Colorectum cell-der...	7.0E-36	[1..252]	[1..252]
gi\|60817324, gi\|... - gi\|61358541\|gb\|AAX41584.1\| amphiregulin [synthetic construct], gi\|60817324\|gb\|AAX36418.1\| amphiregul...	1.0E-35	[1..252]	[1..252]
gi\|109074490 - gi\|109074490\|ref\|XP_001101978.1\| PREDICTED: similar to Amphiregulin precursor (AR) (Colorectum cell-...	1.0E-35	[1..252]	[1..252]
gi\|76655581 - gi\|76655581\|ref\|XP_879918.1\| PREDICTED: similar to FAT tumor suppressor 1 precursor isoform 3 [Bos t...	2.0E-33	[7..242]	[4023..4259]
gi\|124486855, gi... - gi\|82917259\|ref\|XP_890829.1\| PREDICTED: fat tumor suppressor homolog isoform 1 [Mus musculus], gi\|82...	3.0E-33	[13..242]	[3997..4220]
FAT1 - FAT tumor suppressor homolog 1 (Drosophila)	9.0E-33	[7..242]	[4004..4224]
gi\|13929168, gi\|... - gi\|4426629\|gb\|AAD20459.1\| protocadherin [Rattus norvegicus], gi\|13929168\|ref\|NP_114007.1\| FAT tumor ...	2.0E-32	[13..242]	[4013..4223]
gi\|47523808, gi\|... - gi\|47523808\|ref\|NP_999541.1\| amphiregulin [Sus scrofa], gi\|13540808\|gb\|AAK27728.1\| amphiregulin long...	1.0E-31	[1..252]	[1..247]

Back

Predicted Domain #1

Region A:
Residues: [1-252]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG  60
   61 SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT 120
  121 SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER 180
  181 CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK 240
  241 LRQENGNVHA IA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits