YRC Public Data Repository - Protein Structure Prediction

Protein:	SLC5A1
Organism:	Homo sapiens
Length:	664 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLC5A1.

Description	E-value	Query Range	Subject Range
gi\|114686040 - gi\|114686040\|ref\|XP_515093.2\| PREDICTED: solute carrier family 5 (sodium/glucose cotransporter), mem...	0.0	[1..664]	[1..664]
gi\|109093932 - gi\|109093932\|ref\|XP_001112212.1\| PREDICTED: solute carrier family 5 (sodium/glucose cotransporter), ...	0.0	[1..664]	[1..663]
gi\|27807095, gi\|... - gi\|27807095\|ref\|NP_777031.1\| solute carrier family 5 (sodium/glucose cotransporter), member 1 [Bos t...	0.0	[1..664]	[1..664]
gi\|126352558, gi... - gi\|13539197\|emb\|CAC35538.1\| Na+/glucose co-transporter [Equus caballus], gi\|126352558\|ref\|NP_0010753...	0.0	[1..664]	[1..662]
gi\|13277957, gi\|... - gi\|6563312\|gb\|AAF17249.1\|AF208031_1 SGLT1 protein [Mus musculus], gi\|13277957\|gb\|AAH03845.1\| Solute ...	0.0	[1..664]	[1..665]
SC5A1_SHEEP - Sodium/glucose cotransporter 1 OS=Ovis aries GN=SLC5A1 PE=2 SV=1	0.0	[1..664]	[1..664]
gi\|1816433 - gi\|1816433\|dbj\|BAA19172.1\| Na/glucose cotransporter [Rattus norvegicus]	0.0	[1..664]	[1..665]

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Predicted Domain #1

Region A:
Residues: [1-514]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST NRGTVGGFFL  60
   61 AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG FEWNALVLVV VLGWLFVPIY 120
  121 IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL LLYIFTKISA DIFSGAIFIN LALGLNLYLA 180
  181 IFLLLAITAL YTITGGLAAV IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI 240
  241 PTIVSDGNTT FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR 300
  301 CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE CEKYCGTKVG 360
  361 CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS ASTLFTMDIY AKVRKRASEK 420
  421 ELMIAGRLFI LVLIGISIAW VPIVQSAQSG QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV 480
  481 NEPGAFWGLI LGLLIGISRM ITEFAYGTGS CMEP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.982
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [515-664]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNCPTIICGV HYLYFAIILF AISFITIVVI SLLTKPIPDV HLYRLCWSLR NSKEERIDLD  60
   61 AEEENIQEGP KETIEIETQV PEKKKGIFRR AYDLFCGLEQ HGAPKMTEEE EKAMKMKMTD 120
  121 TSEKPLWRTV LNVNGIILVT VAVFCHAYFA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.16
Match:	1sa1E
Description:	TUBULIN-PODOPHYLLOTOXIN: STATHMIN-LIKE DOMAIN COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	2.2516058985787	bayes_pls_golite062009
binding	1.75168508075693	bayes_pls_golite062009
protein binding	1.26741825303674	bayes_pls_golite062009
signal transducer activity	0.799318659408156	bayes_pls_golite062009
molecular transducer activity	0.799318659408156	bayes_pls_golite062009
tubulin binding	0.465732948852681	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: