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View Structure Prediction Details

Protein: GYS1
Organism: Homo sapiens
Length: 737 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYS1.

Description E-value Query
Range		 Subject
Range
gi|62898890 - gi|62898890|dbj|BAD97299.1| glycogen synthase 1 (muscle) variant [Homo sapiens]
 0.0 [1..737] [1..737]
GYS1_MACMU - Glycogen [starch] synthase, muscle OS=Macaca mulatta GN=GYS1 PE=2 SV=1
 0.0 [1..737] [1..737]
GYS1_PONAB - Glycogen [starch] synthase, muscle OS=Pongo abelii GN=GYS1 PE=2 SV=1
gi|55729723 - gi|55729723|emb|CAH91590.1| hypothetical protein [Pongo abelii]
 0.0 [1..737] [1..737]
GYS1_RABIT - Glycogen [starch] synthase, muscle OS=Oryctolagus cuniculus GN=GYS1 PE=1 SV=4
 0.0 [1..737] [1..735]
GYS1_MOUSE - Glycogen [starch] synthase, muscle OS=Mus musculus GN=Gys1 PE=1 SV=2
 0.0 [1..737] [1..738]
GYS1_RAT - Glycogen [starch] synthase, muscle OS=Rattus norvegicus GN=Gys1 PE=1 SV=1
 0.0 [1..737] [1..738]

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Predicted Domain #1
Region A:
Residues: [1-235] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLNRTLSMS SLPGLEDWED EFDLENAVLF EVAWEVANKV GGIYTVLQTK AKVTGDEWGD  60
   61 NYFLVGPYTE QGVRTQVELL EAPTPALKRT LDSMNSKGCK VYFGRWLIEG GPLVVLLDVG 120
  121 ASAWALERWK GELWDTCNIG VPWYDREAND AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH 180
  181 EWLAGVGLCL CRARRLPVAT IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 1rzuA
Description: Crystal structure of the glycogen synthase from A. tumefaciens in complex with ADP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [236-623] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQIYHRYCME RAAAHCAHVF TTVSQITAIE AQHLLKRKPD IVTPNGLNVK KFSAMHEFQN  60
   61 LHAQSKARIQ EFVRGHFYGH LDFNLDKTLY FFIAGRYEFS NKGADVFLEA LARLNYLLRV 120
  121 NGSEQTVVAF FIMPARTNNF NVETLKGQAV RKQLWDTANT VKEKFGRKLY ESLLVGSLPD 180
  181 MNKMLDKEDF TMMKRAIFAT QRQSFPPVCT HNMLDDSSDP ILTTIRRIGL FNSSADRVKV 240
  241 IFHPEFLSST SPLLPVDYEE FVRGCHLGVF PSYYEPWGYT PAECTVMGIP SISTNLSGFG 300
  301 CFMEEHIADP SAYGIYILDR RFRSLDDSCS QLTSFLYSFC QQSRRQRIIQ RNRTERLSDL 360
  361 LDWKYLGRYY MSARHMALSK AFPEHFTY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 2gejA
Description: No description for 2gejA was found.

Predicted Domain #3
Region A:
Residues: [624-737] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPNEADAAQG YRYPRPASVP PSPSLSRHSS PHQSEDEEDP RNGPLEEDGE RYDEDEEAAK  60
   61 DRRNIRAPEW PRRASCTSST SGSKRNSVDT ATSSSLSTPS EPLSPTSSLG EERN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.306 a.60.9 lambda integrase-like, N-terminal domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle