YRC Public Data Repository - Protein Structure Prediction

Protein:	APH1A
Organism:	Homo sapiens
Length:	265 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APH1A.

Description	E-value	Query Range	Subject Range
gi\|12654775 - gi\|12654775\|gb\|AAH01230.1\| Anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens]	0.0	[1..265]	[1..265]
APH1A_MOUSE - Gamma-secretase subunit APH-1A OS=Mus musculus GN=Aph1a PE=2 SV=2	0.0	[1..265]	[1..265]
gi\|194036283 - gi\|194036283\|ref\|XP_001924704.1\| PREDICTED: similar to anterior pharynx defective 1a homolog (C. ele... gi\|57098943 - gi\|57098943\|ref\|XP_540299.1\| PREDICTED: similar to Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alp...	0.0	[1..265]	[1..265]
gi\|110293151, gi... - gi\|34864291\|ref\|XP_217185.2\| PREDICTED: similar to APH1B homolog (C.elegans) [Rattus norvegicus], gi...	1.0E-97	[1..249]	[1..248]
gi\|109016028 - gi\|109016028\|ref\|XP_001100176.1\| PREDICTED: anterior pharynx defective 1 homolog A (C. elegans) isof... gi\|117606357, gi... - gi\|56204870\|emb\|CAI22812.1\| anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens], gi\|3... gi\|114559247 - gi\|114559247\|ref\|XP_001168306.1\| PREDICTED: anterior pharynx defective 1 homolog A isoform 4 [Pan tr...	1.0E-97	[1..247]	[1..247]
gi\|74267816, gi\|... - gi\|77736285\|ref\|NP_001029842.1\| anterior pharynx defective 1 homolog A [Bos taurus], gi\|74267816\|gb\|...	5.0E-97	[1..247]	[1..247]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT  60
   61 DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [106-265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDGRSPISIR QMAYVSGLSF GIISGVFSVI NILADALGPG VVGIHGDSPY YFLTSAFLTA  60
   61 AIILLHTFWG VVFFDACERR RYWALGLVVG SHLLTSGLTF LNPWYEASLL PIYAVTVSMG 120
  121 LWAFITAGGS LRSIQRSLLC RRQEDSRVMV YSALRIPPED

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits